Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Pimagedine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pimagedine SCHEMBL57796 | 0.94 | — | — | |
| Pimagedine SCHEMBL28893570 | 0.89 | — | — | |
| Pimagedine SCHEMBL4915680 | 0.89 | — | — | |
| Pimagedine SCHEMBL19123 | 0.89 | — | — | |
| Pimagedine SCHEMBL8576821 | 0.89 | — | — | |
| Pimagedine SCHEMBL5968075 | 0.77 | BLM (1.00) | — | |
| Pimagedine SCHEMBL7941763 | 0.77 | — | — | |
| Pimagedine SCHEMBL439904 | 0.77 | BLM (1.00) | — | |
| Pimagedine SCHEMBL31430906 | 0.74 | NOS1 (0.61) | — | |
| Pimagedine SCHEMBL31430900 | 0.74 | NOS1 (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114341103-B | Aminoguanhydrazones as retrograde transport stabilizers useful in the treatment of neurological diseases | 圣拉斐尔医院有限公司 | 2023-11-10 | — | — | CN | disclosed |
| EP-3508516-B1 | VULCANIZED RUBBER COMPOSITION AND PRODUCTION PROCESS THEREFOR | MITSUBISHI GAS CHEMICAL CO (JP) | 2020-09-23 | — | — | EP | disclosed |
| CN-106414508-B | Modified rubber for tire, rubber composition for tire using same, and tire | 三菱瓦斯化学株式会社 | 2020-02-21 | — | — | CN | disclosed |
| US-10465016-B2 | Modified rubber for tire, rubber composition for tire using the same, and tire | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2019-11-05 | — | — | US | disclosed |
| EP-3156426-B1 | MODIFIED RUBBER FOR TYRE, RUBBER COMPOSITION FOR TYRE USING SAID MODIFIED RUBBER AND TYRE | MITSUBISHI GAS CHEMICAL CO (JP) | 2019-09-18 | — | — | EP | disclosed |
| EP-3508516-A1 | VULCANIZED RUBBER COMPOSITION AND PRODUCTION PROCESS THEREFOR | Mitsubishi Gas Chemical Company, Inc. (JP) | 2019-07-10 | — | — | EP | disclosed |
| EP-3156394-B1 | ALKYLIDENE AMINOGANIDINE AND SALT THEREOF, MODIFIER COMPOSITION, MODIFIED RUBBER FOR TIRE, RUBBER COMPOSITION FOR TIRE, AND TIRE | MITSUBISHI GAS CHEMICAL CO (JP) | 2019-04-17 | — | — | EP | disclosed |
| US-10246526-B2 | Vulcanized rubber composition and production method thereof | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2019-04-02 | — | — | US | disclosed |
| US-10173973-B2 | Alkylidene aminoguanidine and salt thereof, modifying composition, modified rubber for tire, rubber composition for tire, and tire | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2019-01-08 | — | — | US | disclosed |
| US-20180355074-A1 | VULCANIZED RUBBER COMPOSITION AND PRODUCTION METHOD THEREOF | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2018-12-13 | — | — | US | disclosed |
| US-20170121429-A1 | MODIFIED RUBBER FOR TIRE, RUBBER COMPOSITION FOR TIRE USING THE SAME, AND TIRE | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2017-05-04 | — | — | US | disclosed |
| EP-3156426-A1 | MODIFIED RUBBER FOR TYRE, RUBBER COMPOSITION FOR TYRE USING SAID MODIFIED RUBBER AND TYRE | Mitsubishi Gas Chemical Company, Inc. (JP) | 2017-04-19 | — | — | EP | disclosed |
| EP-3156394-A1 | ALKYLIDENE AMINOGANIDINE AND SALT THEREOF, MODIFIER COMPOSITION, MODIFIED RUBBER FOR TIRE, RUBBER COMPOSITION FOR TIRE, AND TIRE | Mitsubishi Gas Chemical Company, Inc. (JP) | 2017-04-19 | — | — | EP | disclosed |
| EP-2086931-A1 | NOVEL PROCESS | Merck Generics (UK) Limited (GB) | 2009-08-12 | — | — | EP | disclosed |
| WO-2007119109-A3 | PROCESSES FOR PREPARING TEGASEROD MALEATE AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT | MEDICHEM SA (ES) | 2008-06-12 | — | — | WO | disclosed |
| WO-2008055994-A1 | NOVEL PROCESS | GENERICS [UK] LIMITED (GB) | 2008-05-15 | — | — | WO | disclosed |
| WO-2007119109-A2 | PROCESSES FOR PREPARING TEGASEROD MALEATE AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT | MEDICHEM, S.A. (US) | 2007-10-25 | — | — | WO | disclosed |
| WO-2007119109-A2 | PROCESSES FOR PREPARING TEGASEROD MALEATE AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT | MEDICHEM, S.A. (US) | 2007-10-25 | — | — | WO | disclosed |
| WO-1995014679-A1 | TETRAZOLE-SUBSTITUTED UREA ACAT INHIBITORS | PARKE, DAVIS & COMPANY (US) | 1995-06-01 | — | — | WO | disclosed |
| US-5362744-A | Treatnent of athrosclerosis, anticholesterol agents | WARNER-LAMBERT COMPANY (US) | 1994-11-08 | — | — | US | disclosed |