Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Pimagedine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 5/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 4/20 | 0.67 |
| ▸ | NOS1 | P29475 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | AOC1 | P19801 | 1/20 | 0.67 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.67 |
| ▸ | NOS3 | P29474 | 1/20 | 0.67 |
| ▸ | NOS2 | P35228 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | CA5A | P35218 | 2/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | NT5E | P21589 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pimagedine SCHEMBL5968075 | 1.00 | BLM (1.00) | BLMKDM4ETSHRNOS1MEN1 | |
| Pimagedine SCHEMBL28939704 | 0.96 | BLM (0.92) | BLMKDM4ETSHRNOS1MEN1 | |
| Pimagedine SCHEMBL27710814 | 0.89 | BLM (0.80) | BLMKDM4ETSHRNOS1MEN1 | |
| Pimagedine SCHEMBL31430898 | 0.85 | BLM (0.73) | BLMKDM4ETSHRNOS1MEN1 | |
| Pimagedine SCHEMBL57796 | 0.82 | — | — | |
| Hydroxyguanidine SCHEMBL961747 | 0.80 | BLM (0.67) | BLMKDM4ETSHRNOS1MEN1 | |
| Hydroxyguanidine SCHEMBL20520386 | 0.80 | BLM (0.67) | BLMKDM4ETSHRNOS1MEN1 | |
| Hydroxyguanidine SCHEMBL3574406 | 0.77 | BLM (0.62) | BLMKDM4ETSHRNOS1MEN1 | |
| Sulfuric Acid SCHEMBL5581558 | 0.77 | BLM (0.62) | BLMKDM4ETSHRNOS1MEN1 | |
| Hydroxyguanidine SCHEMBL8874244 | 0.77 | BLM (0.62) | BLMKDM4ETSHRNOS1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 587 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120136744-A | Novel intermediate of 5-cyanoindole and preparation method thereof | 台州职业技术学院 | 2025-06-13 | — | — | CN | claimed |
| CN-119753848-A | Amino guanidine oxalate second-order nonlinear optical crystal material, preparation and application thereof | 同济大学 | 2025-04-04 | — | — | CN | claimed |
| CN-119332364-A | Antibacterial deodorizing fabric and preparation process thereof | 罗莱生活科技股份有限公司 | 2025-01-21 | — | — | CN | claimed |
| CN-119332363-A | Deodorizing fiber, deodorizing fabric and preparation process of deodorizing fiber and deodorizing fabric | 罗莱生活科技股份有限公司 | 2025-01-21 | — | — | CN | claimed |
| WO-2025000625-A1 | CHEMICAL COOLANT AND USE THEREOF IN AEROSOL-BASED FIRE EXTINGUISHING | 湖北及安盾消防科技有限公司 | 2025-01-02 | — | — | WO | claimed |
| CN-118754829-A | Energetic salt containing multiple dinitramide anions, preparation method thereof and solid propellant energetic oxidant | 湖北航天化学技术研究所 | 2024-10-11 | — | — | CN | claimed |
| US-12042777-B2 | Deodorant composition suitable for aldehyde-based gas or ketone-based gas | TOAGOSEI CO., LTD. (JP) | 2024-07-23 | — | — | US | claimed |
| CN-118290308-A | Ionic crosslinking agent and preparation method thereof, and aqueous acrylic pressure-sensitive adhesive for high-initial-adhesion high-holding-strength adhesive paper labels and preparation method thereof | 万华化学集团股份有限公司 | 2024-07-05 | — | — | CN | claimed |
| US-20240130956-A1 | HAIR COSMETIC COMPOSITION | KAO CORPORATION (JP) | 2024-04-25 | — | — | US | claimed |
| CN-117159523-A | Application of aminoguanidine compound in preparation of medicines for treating gosling gout caused by type 2 goose astrovirus | 南京农业大学 | 2023-12-05 | — | — | CN | claimed |
| CN-1107097-C | chemical mechanical polishing composition and method | CHANGXING CHEMICAL INDUSTRY CO (CN) | 2003-04-30 | — | — | CN | claimed |
| US-20020115724-A1 | Methods and agents for inhibiting protein aging | CERAMI ANTHONY (US) | 2002-08-22 | — | — | US | claimed |
| EP-1093422-A2 | PYROTECHNIC GAS GENERANT COMPOSITION INCLUDING HIGH OXYGEN BALANCE FUEL | ATLANTIC RESEARCH CORPORATION (US) | 2001-04-25 | — | — | EP | claimed |
| CN-1282775-A | chemical mechanical polishing composition and method | CHANGXING CHEMICAL INDUSTRY CO (CN) | 2001-02-07 | — | — | CN | claimed |
| US-6114323-A | DIABETIC KIDNEY DISEASE; ADMINISTERING AMINOGUANIDINE | THE ROCKEFELLER UNIVERSITY (US) | 2000-09-05 | — | — | US | claimed |
| WO-2000000365-A9 | PYROTECHNIC GAS GENERANT COMPOSITION INCLUDING HIGH OXYGEN BALANCE FUEL | ATLANTIC RES CORP (US) | 2000-06-08 | — | — | WO | claimed |
| WO-2000000365-A2 | PYROTECHNIC GAS GENERANT COMPOSITION INCLUDING HIGH OXYGEN BALANCE FUEL | ATLANTIC RESEARCH CORPORATION (US) | 2000-01-06 | — | — | WO | claimed |
| US-5852009-A | Compositions, including pharmaceutical compositions, for inhibiting the advanced glycosylation of proteins, and therapeutic methods based thereon | THE ROCKEFELLER UNIVERSITY (US) | 1998-12-22 | — | — | US | claimed |
| US-5559243-A | Processes for producing a salt of N-guanidino thiourea and 3-amino-5-mercapto-1,2,4-triazole | NIPPON CARBIDE KOGYO KABUSHIKI KAISHA (JP) | 1996-09-24 | — | — | US | claimed |
| US-5128360-A | Inhibition of advanced glycosylation end products of target proteins using aminoguanidine and-or hydrazinohistidine | THE ROCKEFELLER UNIVERSITY (US) | 1992-07-07 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240130956-A1 | HAIR COSMETIC COMPOSITION | PHOSPHO1, ODC1, H1-0 | BLM 4353/4885KDM4E 1056/4885TSHR 4201/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.