Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 15/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3318631 | 0.85 | MAPK14 (0.51) | MAPK14MAPK11MAPK13MAPK12CYP3A4 | |
| SCHEMBL3815355 | 0.81 | MAPK14 (0.51) | MAPK14MAPK11MAPK13MAPK12CYP3A4 | |
| SCHEMBL3820383 | 0.79 | MAPK11 (0.45) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL3822037 | 0.79 | MAPK11 (0.43) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL3317604 | 0.76 | LMNA (0.52) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL13538845 | 0.74 | MAPK14 (0.45) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL3827193 | 0.74 | MAPK14 (0.44) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL3821217 | 0.74 | MAPK14 (0.45) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL3317830 | 0.73 | MAPK14 (0.44) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL13538846 | 0.72 | DHODH (0.49) | MAPK14MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1635824-B1 | 5-MEMBERED HETEROCYCLE-BASED P-38 INHIBITORS | NOVARTIS AG (CH) | 2009-08-19 | — | — | EP | claimed |