Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3317604 | 0.85 | LMNA (0.52) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL3819082 | 0.81 | MAPK14 (0.49) | MAPK14MAPK11MAPK13MAPK12CYP3A4 | |
| SCHEMBL3315767 | 0.77 | MAPK14 (0.58) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL3319102 | 0.76 | MAPK14 (0.58) | MAPK14MAPK11CYP3A4 | |
| SCHEMBL3318631 | 0.76 | MAPK14 (0.51) | MAPK14MAPK11MAPK13MAPK12CYP3A4 | |
| SCHEMBL3314066 | 0.75 | MAPK14 (0.59) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL3822037 | 0.75 | MAPK11 (0.43) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL5025037 | 0.74 | MAPK14 (0.53) | MAPK14MAPK11MAPK13MAPK12BRAF | |
| SCHEMBL3313975 | 0.74 | MAPK14 (0.50) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL3317469 | 0.74 | HPGDS (0.56) | MAPK14MAPK11MAPK13MAPK12CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1635824-B1 | 5-MEMBERED HETEROCYCLE-BASED P-38 INHIBITORS | NOVARTIS AG (CH) | 2009-08-19 | — | — | EP | claimed |