SCHEMBL3819136

SCHEMBL3819136

CC(C)(C)OC(=O)N[C@@H](CC=Cc1ccc(Br)cc1)C(=O)O

nearest known ligand 0.54

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CTSS P25774 5/20 0.54
CTSK P43235 5/20 0.54
PPARA Q07869 7/20 0.50
PPARG P37231 6/20 0.50
NPC1 O15118 1/20 0.49
RECQL P46063 1/20 0.49
RAB9A P51151 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
ALDH1A1 P00352 1/20 0.46
MAPT P10636 1/20 0.46
GRIK1 P39086 1/20 0.45
GRIK2 Q13002 1/20 0.45
CTSB P07858 2/20 0.45
ACE P12821 1/20 0.44
AAK1 Q2M2I8 1/20 0.43
PPARD Q03181 2/20 0.43
CACNA1B Q00975 1/20 0.43
CTSL P07711 1/20 0.43
PIN1 Q13526 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3819131 1.00 CTSS (0.54) CTSSCTSKPPARAPPARGNPC1
SCHEMBL3583856 0.90 PPARA (0.54) CTSSCTSKPPARAPPARGCTSB
SCHEMBL7453573 0.90 PPARA (0.54) CTSSCTSKPPARAPPARGCTSB
SCHEMBL16279346 0.90 PPARA (0.54) CTSSCTSKPPARAPPARGCTSB
SCHEMBL16279348 0.90 PPARA (0.54) CTSSCTSKPPARAPPARGCTSB
SCHEMBL25054171 0.90 PPARA (0.54) CTSSCTSKPPARAPPARGCTSB
SCHEMBL16279350 0.90 PPARA (0.54) CTSSCTSKPPARAPPARGCTSB
SCHEMBL13897570 0.89 CTSK (0.50) CTSSCTSKPPARAPPARGNPC1
SCHEMBL16278537 0.88 PPARA (0.54) CTSSCTSKPPARAPPARGSMN1; SMN2
SCHEMBL16278539 0.88 PPARA (0.54) CTSSCTSKPPARAPPARGSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2086956-A1 INHIBITORS OF IKK- BETA SERINE-THREONINE PROTEIN KINASE Chroma Therapeutics Limited (GB) 2009-08-12 EP disclosed
WO-2008053185-A1 INHIBITORS OF IKK-β SERINE-THREONINE PROTEIN KINASE CHROMA THERAPEUTICS LTD. (GB) 2008-05-08 WO disclosed