SCHEMBL381922

SCHEMBL381922

O=C(NC1CC1)OCc1ccccc1

nearest known ligand 0.85

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.85
GAA P10253 1/20 0.85
TSHR P16473 1/20 0.81
EPHX1 P07099 1/20 0.71
DPP4 P27487 6/20 0.63
DPP7 Q9UHL4 6/20 0.63
KCNH2 Q12809 3/20 0.63
CTSL P07711 1/20 0.63
CTSB P07858 1/20 0.63
CTSK P43235 1/20 0.63
MEN1 O00255 1/20 0.60
KMT2A Q03164 1/20 0.60
TLR4 O00206 1/20 0.57
CA1 P00915 1/20 0.56
CA2 P00918 1/20 0.56
ACHE P22303 1/20 0.56
KDM1A O60341 1/20 0.56
MAOB P27338 1/20 0.56
CPB1 P15086 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3948456 1.00 ALDH1A1 (0.85) ALDH1A1GAATSHREPHX1DPP4
SCHEMBL3948461 1.00 ALDH1A1 (0.85) ALDH1A1GAATSHREPHX1DPP4
Hydrochloric Acid SCHEMBL28135182 0.98 ALDH1A1 (0.83) ALDH1A1GAATSHREPHX1DPP4
SCHEMBL761181 0.94 ALDH1A1 (0.76) ALDH1A1GAATSHREPHX1DPP4
SCHEMBL9555876 0.94 ALDH1A1 (0.76) ALDH1A1GAATSHREPHX1DPP4
SCHEMBL851220 0.94 ALDH1A1 (0.76) ALDH1A1GAATSHREPHX1DPP4
Cyclobutylcarbamic Acid Benzyl Ester SCHEMBL332814 0.93 EPHX1 (0.76) ALDH1A1GAATSHREPHX1DPP4
SCHEMBL7198149 0.93 EPHX1 (0.81) ALDH1A1GAATSHREPHX1DPP4
SCHEMBL14337555 0.92 ALDH1A1 (0.74) ALDH1A1GAATSHREPHX1DPP4
SCHEMBL12879965 0.92 ALDH1A1 (0.74) ALDH1A1GAATSHREPHX1DPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2408739-A1 A PROCESS FOR THE PREPARATION OF 6-(7-((1-AMINOCYCLOPROPYL)METHOXY)-6-METHOXYQUINOLIN-4-YLOXY)-N-METHYL-1-NAPHTHAMIDE AND SYNTHETIC INTERMEDIATES THEREOF EOS Ethical Oncology Science S.p.A. In Abbreviated From EOS S.p.A. (IT) 2012-01-25 EP claimed
WO-2010105761-A1 A PROCESS FOR THE PREPARATION OF 6-(7-((1-AMINOCYCLOPROPYL)METHOXY)-6-METHOXYQUINOLIN-4-YLOXY)-N-METHYL-1-NAPHTHAMIDE AND SYNTHETIC INTERMEDIATES THEREOF EOS ETHICAL ONCOLOGY SCIENCE S.P.A. IN ABBREVIATED FORM EOS S.P.A. (IT) 2010-09-23 WO claimed
EP-3440075-B1 BENZO[B]FURANS AS BROMODOMAIN INHIBITORS GLAXOSMITHKLINE IP NO 2 LTD (GB) 2020-01-29 EP disclosed
CN-110291074-A The method for preparing cyclopropyl diketopiperazine and key intermediate DS-5272 意大利合成制造有限公司 2019-09-27 CN disclosed
WO-2017174620-A1 BENZO[B]FURANS AS BROMODOMAIN INHIBITORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) 2017-10-12 WO disclosed
CN-103282352-B Benzamides and nicotinamide as SYK regulator 波托拉医药品公司 2016-08-10 CN disclosed
US-8691814-B2 Deazapurines and uses thereof EISAI R&D MANAGEMENT CO., LTD. (JP) 2014-04-08 US disclosed
CN-103282352-A Benzamides and nicotinamides as syk modulators PORTOLA PHARM INC 2013-09-04 CN disclosed
EP-1992613-B1 PROCESS FOR PRODUCTION OF 3,4-DISUBSTITUTED PYRROLIDINE DERIVATIVE AND INTERMEDIATE FOR THE PRODUCTION KYORIN SEIYAKU KK (JP) 2013-01-30 EP disclosed
CN-102892767-A Compounds for the treatment of hepatitis c BRISTOL MYERS SQUIBB CO (US) 2013-01-23 CN disclosed
WO-2011044502-A9 ANTIBACTERIAL AMINOGLYCOSIDE ANALOGS ACHAOGEN, INC. (US) 2012-02-23 WO disclosed
EP-1200435-A1 PURINE DERIVATIVES INHIBITORS OF TYROSINE PROTEIN KINASE SYK Novartis AG (CH) 2002-05-02 EP disclosed
WO-2001009134-A1 PURINE DERIVATIVES INHIBITORS OF TYROSINE PROTEIN KINASE SYK NOVARTIS AG (CH) 2001-02-08 WO disclosed
CN-1283189-A Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors DIMENSIONAL PHARM INC (US) 2001-02-07 CN disclosed
US-5864043-A CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST KARL THOMAE GMBH (DE) 1999-01-26 US disclosed
US-5541229-A ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS DR. KARL THOMAE GMBH (DE) 1996-07-30 US disclosed
US-4863903-A RENIN ENZYME INHIBITORS, HYPOTENSIVE AGENTS CIBA-GEIGY CORPORATION (US) 1989-09-05 US disclosed
US-4719288-A HYPOTENSIVE CIBA-GEIGY CORPORATION (US) 1988-01-12 US disclosed
US-4613676-A PEPTIDES CIBA-GEIGY CORPORATION (US) 1986-09-23 US disclosed
EP-0143746-A2 5-Amino 4-hydroxy-valeryl-substituted derivatives CIBA-GEIGY AG (CH) 1985-06-05 EP disclosed