Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.76 |
| ▸ | GAA | P10253 | 1/20 | 0.76 |
| ▸ | TSHR | P16473 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | DPP4 | P27487 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.60 |
| ▸ | CTSL | P07711 | 1/20 | 0.60 |
| ▸ | CTSB | P07858 | 1/20 | 0.60 |
| ▸ | CTSK | P43235 | 1/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8393719 | 0.98 | EPHX1 (0.84) | EPHX1ALDH1A1GAATSHRMEN1 | |
| SCHEMBL1424064 | 0.98 | EPHX1 (0.84) | EPHX1ALDH1A1GAATSHRMEN1 | |
| Bicarbonate SCHEMBL6203780 | 0.97 | EPHX1 (0.82) | EPHX1ALDH1A1GAATSHRMEN1 | |
| Cyclobutylcarbamic Acid Benzyl Ester SCHEMBL332814 | 0.97 | EPHX1 (0.76) | EPHX1ALDH1A1GAATSHRMEN1 | |
| Methyl Alcohol SCHEMBL6780968 | 0.95 | EPHX1 (0.80) | EPHX1ALDH1A1GAATSHRMEN1 | |
| Cyclobutylcarbamic Acid Benzyl Ester SCHEMBL579215 | 0.95 | EPHX1 (0.74) | EPHX1ALDH1A1GAATSHRMEN1 | |
| SCHEMBL14612363 | 0.94 | EPHX1 (0.78) | EPHX1ALDH1A1GAATSHRMEN1 | |
| Dimethylamine SCHEMBL8326428 | 0.94 | EPHX1 (0.78) | EPHX1ALDH1A1GAATSHRMEN1 | |
| SCHEMBL3948456 | 0.93 | ALDH1A1 (0.85) | EPHX1ALDH1A1GAATSHRMEN1 | |
| SCHEMBL381922 | 0.93 | ALDH1A1 (0.85) | EPHX1ALDH1A1GAATSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230255922-A1 | TREPROSTINIL PRODRUGS | UNITED THERAPEUTICS CORPORATION (US) | 2023-08-17 | — | — | US | disclosed |
| US-11672775-B2 | Treprostinil prodrugs | UNITED THERAPEUTICS CORPORATION (US) | 2023-06-13 | — | — | US | disclosed |
| US-20230133465-A1 | COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING NEURODEGENERATIVE DISORDERS | ALZHEON, INC. | 2023-05-04 | — | — | US | disclosed |
| US-20210121433-A1 | TREPROSTINIL PRODRUGS | UNITED THERAPEUTICS CORPORATION (US) | 2021-04-29 | — | — | US | disclosed |
| CN-110678174-A | Prodrugs of treprostinil | 联合治疗学有限公司 | 2020-01-10 | — | — | CN | disclosed |
| EP-3515430-A1 | TREPROSTINIL PRODRUGS | United Therapeutics Corporation (US) | 2019-07-31 | — | — | EP | disclosed |
| CN-109966294-A | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | 艾伯维爱尔兰无限公司 | 2019-07-05 | — | — | CN | disclosed |
| CN-109897038-A | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | 艾伯维爱尔兰无限公司 | 2019-06-18 | — | — | CN | disclosed |
| US-20180153847-A1 | TREPROSTINIL PRODRUGS | UNITED THERAPEUTICS CORPORATION (US) | 2018-06-07 | — | — | US | disclosed |
| WO-2018058124-A1 | TREPROSTINIL PRODRUGS | UNITED THERAPEUTICS CORPORATION (US) | 2018-03-29 | — | — | WO | disclosed |
| WO-2002024629-A1 | ZWITTERIONIC TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2002-03-28 | — | — | WO | disclosed |
| EP-0858444-A4 | CYCLOPENTYL TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1999-12-01 | — | — | EP | disclosed |
| WO-1999012034-A1 | AMINE COMPOUNDS AND COMBINATORIAL LIBRARIES COMPRISING SAME | ISIS PHARMACEUTICALS, INC. (US) | 1999-03-11 | — | — | WO | disclosed |
| US-5864043-A | CARDIOVASCULAR DISORDERS AND ANGIOTENSIN ANTAGONIST | KARL THOMAE GMBH (DE) | 1999-01-26 | — | — | US | disclosed |
| EP-0865439-A4 | COMBINATORIAL LIBRARIES HAVING AMINODIOL MONOMER SUBUNITS | ISIS PHARMACEUTICALS INC (US) | 1998-11-11 | — | — | EP | disclosed |
| EP-0865439-A1 | COMBINATORIAL LIBRARIES HAVING AMINODIOL MONOMER SUBUNITS | ISIS PHARMACEUTICALS, INC. (US) | 1998-09-23 | — | — | EP | disclosed |
| EP-0858444-A1 | CYCLOPENTYL TACHYKININ RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997014671-A1 | CYCLOPENTYL TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1997-04-24 | — | — | WO | disclosed |
| WO-1996040672-A1 | COMBINATORIAL LIBRARIES HAVING AMINODIOL MONOMER SUBUNITS | ISIS PHARMACEUTICALS, INC. (US) | 1996-12-19 | — | — | WO | disclosed |
| US-5541229-A | ANGIOITENSIN II ANTAGONIST AS HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS AND CARDIOVASCULAR DISORDERS | DR. KARL THOMAE GMBH (DE) | 1996-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230133465-A1 | COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING NEURODEGENERATIVE DISORDERS | PSEN2, CLN6, PSEN1 | EPHX1 1134/4885ALDH1A1 1785/4885GAA 41/4885 |
| US-20180153847-A1 | TREPROSTINIL PRODRUGS | TYMP, TK1, DCTPP1 | EPHX1 394/4885ALDH1A1 758/4885GAA 1102/4885 |
| US-20210121433-A1 | TREPROSTINIL PRODRUGS | TYMP, TK1, DCTPP1 | EPHX1 394/4885ALDH1A1 758/4885GAA 1102/4885 |
| US-11672775-B2 | Treprostinil prodrugs | TYMP, TK1, DCTPP1 | EPHX1 394/4885ALDH1A1 758/4885GAA 1102/4885 |
| US-20230255922-A1 | TREPROSTINIL PRODRUGS | TYMP, TK1, DCTPP1 | EPHX1 394/4885ALDH1A1 758/4885GAA 1102/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.