Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3821083 | 0.89 | GAA (0.41) | SMN1; SMN2KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL3824171 | 0.86 | SMN1; SMN2 (0.45) | SMN1; SMN2GRM5ALDH1A1RAB9ALMNA | |
| SCHEMBL3816897 | 0.83 | ALDH1A1 (0.40) | SMN1; SMN2KMT2AGRM5ALDH1A1RAB9A | |
| SCHEMBL3821167 | 0.82 | HPGD (0.55) | SMN1; SMN2KMT2AGRM5MAPTALDH1A1 | |
| SCHEMBL3819293 | 0.80 | TRPC3 (0.40) | SMN1; SMN2GRM5MAPTMAPK1PKM | |
| SCHEMBL3814391 | 0.80 | TRPC3 (0.40) | SMN1; SMN2GRM5MAPTMAPK1PKM | |
| SCHEMBL3816059 | 0.79 | SMN1; SMN2 (0.43) | SMN1; SMN2KMT2AMEN1GRM5ALDH1A1 | |
| SCHEMBL928811 | 0.79 | GRM5 (0.60) | SMN1; SMN2GRM5MAPTALDH1A1HPGD | |
| SCHEMBL3819023 | 0.77 | SPR (0.41) | SMN1; SMN2MAPTALDH1A1RAB9ALMNA | |
| SCHEMBL3817222 | 0.74 | ALDH1A1 (0.40) | SMN1; SMN2KMT2AMAPTALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |