Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.35 |
| ▸ | CFTR | P13569 | 3/20 | 0.35 |
| ▸ | LHCGR | P22888 | 3/20 | 0.34 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.34 |
| ▸ | TRPC6 | Q9Y210 | 2/20 | 0.34 |
| ▸ | TACR2 | P21452 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | TACR3 | P29371 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3820338 | 0.90 | GRM5 (0.36) | GRM5CFTRLHCGRTRPC3TRPC6 | |
| SCHEMBL3817023 | 0.89 | GRM5 (0.38) | GRM5CFTRTRPC3TRPC6 | |
| SCHEMBL3812551 | 0.87 | GRM5 (0.36) | GRM5P2RX7CFTR | |
| SCHEMBL3812048 | 0.85 | P2RX7 (0.36) | GRM5P2RX7CFTR | |
| SCHEMBL3812051 | 0.84 | DRD1 (0.47) | GRM5LHCGRDRD1 | |
| SCHEMBL1870946 | 0.84 | GRM5 (0.54) | GRM5 | |
| SCHEMBL3818848 | 0.83 | GRM5 (0.36) | GRM5P2RX7LHCGRTRPC3TRPC6 | |
| SCHEMBL3819893 | 0.83 | GRM5 (0.38) | GRM5P2RX7CFTRTRPC3TRPC6 | |
| SCHEMBL3822486 | 0.83 | RIPK1 (0.46) | GRM5P2RX7CFTRTRPC3TRPC6 | |
| SCHEMBL3816636 | 0.81 | KMT2A (0.41) | GRM5P2RX7DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |