Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 15/20 | 0.63 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.54 |
| ▸ | GSK3A | P49840 | 4/20 | 0.54 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.51 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.48 |
| ▸ | TDP2 | O95551 | 2/20 | 0.48 |
| ▸ | STK10 | O94804 | 1/20 | 0.47 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL934146 | 0.91 | GSK3B (0.65) | GSK3BPTGS2GSK3AADORA2AADORA1 | |
| SCHEMBL3819171 | 0.88 | GSK3B (0.51) | GSK3BPTGS2GSK3AADORA2AADORA1 | |
| SCHEMBL18049421 | 0.88 | GSK3B (0.60) | GSK3BPTGS2GSK3AADORA2AADORA1 | |
| SCHEMBL18049438 | 0.88 | GSK3B (0.51) | GSK3BPTGS2GSK3AADORA2AADORA1 | |
| SCHEMBL3816794 | 0.85 | GSK3B (0.67) | GSK3BPTGS2GSK3A | |
| SCHEMBL3823530 | 0.85 | GSK3B (0.51) | GSK3BPTGS2GSK3A | |
| SCHEMBL27950468 | 0.84 | PTGS2 (0.69) | GSK3BPTGS2GSK3A | |
| SCHEMBL30999908 | 0.84 | GSK3B (0.55) | GSK3BGSK3AADORA2AADORA1BRDT | |
| SCHEMBL18049423 | 0.83 | PTGS2 (0.71) | GSK3BPTGS2GSK3AADORA2AADORA1 | |
| SCHEMBL13204641 | 0.83 | GSK3B (0.52) | GSK3BGSK3AADORA2AADORA1BRDT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016144352-A2 | THERAPEUTIC COMPOSITIONS INCLUDING ACRYLAMIDO COMPOUNDS OR PHENYL-SUBSTITUTED MALEIMIDE COMPOUNDS, VARIANTS THEREOF AND METHODS OF USING THE SAME | STEALTH PEPTIDES INTERNATIONAL, INC. (MC) | 2016-09-15 | — | — | WO | disclosed |
| EP-2091531-A2 | PHENYL SUBSTITUTED MALEIMIDES AS MEDICAMENTS FOR BLOCKING DEGENERATIVE TISSUE DAMAGES BY INHIBITING MPT | Congenia S.r.l. (IT) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008067863-A2 | PHENYL SUBSTITUTED MALEIMIDES AS MEDICAMENTS FOR BLOCKING DEGENERATIVE TISSUE DAMAGES BY INHIBITING MPT | CONGENIA S.R.L. (IT) | 2008-06-12 | — | — | WO | disclosed |