Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 6/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.32 |
| ▸ | TPH1 | P17752 | 4/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3820245 | 0.90 | GRM5 (0.37) | GRM5HCRTR1HCRTR2 | |
| SCHEMBL1009122 | 0.86 | GRM5 (0.54) | GRM5TPH1 | |
| SCHEMBL3817661 | 0.83 | NPSR1 (0.33) | GRM5MAPK1NPSR1MEN1KMT2A | |
| SCHEMBL3815643 | 0.82 | MAPT (0.38) | GRM5MAPK1NPSR1 | |
| SCHEMBL4196332 | 0.82 | FNTA (0.30) | — | |
| SCHEMBL3820067 | 0.81 | DRD1 (0.42) | GRM5MAPK1NPSR1 | |
| SCHEMBL3813529 | 0.81 | F11 (0.40) | GRM5MAPK1NPSR1MEN1KMT2A | |
| SCHEMBL3816988 | 0.80 | F11 (0.39) | GRM5MAPK1NPSR1 | |
| SCHEMBL1009988 | 0.79 | GRM5 (0.54) | GRM5KMT2A | |
| SCHEMBL3818785 | 0.79 | DRD1 (0.36) | GRM5MGLLMAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | claimed |
| EP-2090576-A1 | 6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators | Merz Pharma GmbH & Co.KGaA (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |