Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 9/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 9/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.48 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5457486 | 0.99 | CYP11B1 (0.47) | CYP11B1CYP11B2CYP19A1CYP17A1NPY5R | |
| SCHEMBL3819127 | 0.92 | CYP11B1 (0.53) | CYP11B1CYP11B2CYP19A1CYP17A1NPY5R | |
| SCHEMBL3823962 | 0.87 | CHRM1 (0.50) | CYP11B1CYP11B2CYP19A1CYP17A1CYP2C19 | |
| Hydrochloric Acid SCHEMBL5456114 | 0.86 | CHRM1 (0.49) | CYP11B1CYP11B2CYP19A1CYP17A1CYP2C19 | |
| SCHEMBL4866507 | 0.79 | CYP2A6 (0.50) | CYP11B1CYP11B2CYP19A1CYP17A1CYP2C19 | |
| SCHEMBL3818879 | 0.79 | CYP2A6 (0.45) | CYP11B1CYP11B2CYP19A1CYP17A1CYP2C19 | |
| Hydrochloric Acid SCHEMBL4871270 | 0.78 | CYP2C19 (0.49) | CYP11B1CYP11B2CYP19A1CYP17A1CYP2C19 | |
| SCHEMBL3822034 | 0.78 | CYP2C19 (0.44) | CYP11B1CYP11B2CYP19A1CYP17A1CYP2C19 | |
| SCHEMBL3820831 | 0.78 | CYP2A6 (0.44) | CYP11B1CYP11B2CYP19A1CYP17A1CYP2C19 | |
| SCHEMBL7584182 | 0.77 | ESR1 (0.40) | CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8278338-B2 | Saturated and unsaturated 3-pyridyl-benzocycloalkylmethyl-amines for use in treating pain, depression and/or anxiety | GRUENENTHAL GMBH (DE) | 2012-10-02 | — | — | US | claimed |
| EP-1758860-B1 | SATURATED AND UNSATURATED 3-PYRIDYL-BENZOCYCLOALKYLMETHYL-AMINES FOR USE IN THE TREATMENT OF PAINS, DEPRESSIONS AND ANXIETY STATES | GRUENENTHAL GMBH (DE) | 2009-09-02 | — | — | EP | claimed |
| US-20070203192-A1 | Saturated and unsaturated 3-pyridyl-benzocycloalkylmethyl-amines for use in treating pain, depression and/or anxiety | GRUENENTHAL GMBH | 2007-08-30 | — | — | US | claimed |
| US-8278338-B2 | Saturated and unsaturated 3-pyridyl-benzocycloalkylmethyl-amines for use in treating pain, depression and/or anxiety | GRUENENTHAL GMBH (DE) | 2012-10-02 | — | — | US | disclosed |
| EP-1758860-B1 | SATURATED AND UNSATURATED 3-PYRIDYL-BENZOCYCLOALKYLMETHYL-AMINES FOR USE IN THE TREATMENT OF PAINS, DEPRESSIONS AND ANXIETY STATES | GRUENENTHAL GMBH (DE) | 2009-09-02 | — | — | EP | disclosed |
| US-20070203192-A1 | Saturated and unsaturated 3-pyridyl-benzocycloalkylmethyl-amines for use in treating pain, depression and/or anxiety | GRUENENTHAL GMBH | 2007-08-30 | — | — | US | disclosed |
| EP-1758860-A1 | SATURATED AND UNSATURATED 3-PYRIDYL-BENZOCYCLOALKYLMETHYL-AMINES FOR USE IN THE TREATMENT OF PAINS, DEPRESSIONS AND ANXIETY STATES | Grünenthal GmbH (DE) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123681-A1 | SATURATED AND UNSATURATED 3-PYRIDYL-BENZOCYCLOALKYLMETHYL-AMINES FOR USE IN THE TREATMENT OF PAINS, DEPRESSIONS AND ANXIETY STATES | Grünenthal GmbH (DE) | 2005-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203192-A1 | Saturated and unsaturated 3-pyridyl-benzocycloalkylmethyl-amines for use in treating pain, depression and/or anxiety | OPRK1, OPRM1, OPRL1 | CYP11B1 979/4885CYP11B2 900/4885CYP19A1 878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.