Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR5 | P32302 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MYC | P01106 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL383489 | 0.83 | ALDH1A1 (0.62) | CXCR5ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL12569955 | 0.79 | ALDH1A1 (0.60) | CXCR5ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL4857330 | 0.78 | PTGER1 (0.45) | CXCR5ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL1989131 | 0.77 | ALDH1A1 (0.62) | ALDH1A1KDM4EHPGDHSD17B10MYC | |
| SCHEMBL27248901 | 0.76 | ALDH1A1 (0.57) | ALDH1A1KDM4EHPGDHSD17B10MYC | |
| SCHEMBL30675634 | 0.76 | ALDH1A1 (0.70) | ALDH1A1KDM4EHPGDHSD17B10MYC | |
| SCHEMBL305252 | 0.76 | ALDH1A1 (0.70) | ALDH1A1KDM4EHPGDHSD17B10MYC | |
| SCHEMBL4146424 | 0.76 | KDM4E (0.49) | CXCR5ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL1899339 | 0.76 | KDM4E (0.54) | ALDH1A1KDM4EHPGDHSD17B10MAPK8 | |
| SCHEMBL5708141 | 0.75 | KDM4E (0.46) | CXCR5ALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101625-B2 | Pyrimidinones as Casein Kinase II (CK2) modulators | EXELIXIS, INC. (US) | 2012-01-24 | — | — | US | disclosed |
| EP-1948617-B1 | PYRIMIDINONES AS CASEIN KINASE II (CK2) MODULATORS | EXELIXIS INC (US) | 2011-07-27 | — | — | EP | disclosed |