Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.70 |
| ▸ | HPGD | P15428 | 2/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.70 |
| ▸ | MYC | P01106 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CASR | P41180 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MPO | P05164 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL305252 | 1.00 | ALDH1A1 (0.70) | ALDH1A1KDM4EHPGDHSD17B10MYC | |
| SCHEMBL9183165 | 0.98 | ALDH1A1 (0.68) | ALDH1A1KDM4EHPGDHSD17B10MYC | |
| Bicarbonate SCHEMBL4612198 | 0.98 | ALDH1A1 (0.68) | ALDH1A1KDM4EHPGDHSD17B10MYC | |
| SCHEMBL28496827 | 0.98 | ALDH1A1 (0.68) | ALDH1A1KDM4EHPGDHSD17B10MYC | |
| Boric Acid SCHEMBL25416181 | 0.96 | ALDH1A1 (0.66) | ALDH1A1KDM4EHPGDHSD17B10MYC | |
| SCHEMBL28657558 | 0.91 | KDM4E (0.60) | ALDH1A1KDM4EHPGDHSD17B10MYC | |
| SCHEMBL39857 | 0.89 | ALDH1A1 (0.55) | ALDH1A1KDM4EHPGDHSD17B10MAPK1 | |
| Hydrochloric Acid SCHEMBL699717 | 0.87 | ALDH1A1 (0.53) | ALDH1A1KDM4EHPGDHSD17B10KMT2A | |
| SCHEMBL32674573 | 0.86 | MYC (0.57) | ALDH1A1KDM4EHPGDHSD17B10MYC | |
| SCHEMBL9726590 | 0.85 | KDM4E (0.52) | ALDH1A1KDM4EHPGDHSD17B10MYC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12630549-B2 | Pyrazoleamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2026-05-19 | — | — | US | disclosed |
| US-20230382911-A1 | PYRAZOLEAMIDE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230382911-A1 | PYRAZOLEAMIDE DERIVATIVES | P2RY1, P2RX1, P2RX5 | ALDH1A1 203/4885KDM4E 2850/4885HPGD 611/4885 |
| US-12630549-B2 | Pyrazoleamide derivatives | CYP11B2, CYP11B1, ADRA1B | ALDH1A1 439/4885KDM4E 3127/4885HPGD 1203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.