Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 9/20 | 0.46 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3820953 | 0.87 | NOTUM (0.41) | ACACBPTGESHRH3ALDH1A1MAPT | |
| SCHEMBL5481745 | 0.82 | MAPT (0.55) | PTGESALDH1A1MAPT | |
| SCHEMBL31381229 | 0.77 | NOTUM (0.56) | PTGES | |
| SCHEMBL3820949 | 0.77 | NOTUM (0.56) | PTGES | |
| SCHEMBL8127380 | 0.76 | ADRB1 (0.41) | PTGESALDH1A1 | |
| SCHEMBL31381251 | 0.76 | PDK2 (0.49) | PTGESALDH1A1MAPT | |
| SCHEMBL6206254 | 0.72 | ALDH1A1 (0.51) | ALDH1A1MAPT | |
| SCHEMBL13723405 | 0.71 | NOTUM (0.44) | PTGESALDH1A1 | |
| SCHEMBL29621605 | 0.71 | NOTUM (0.53) | PTGES | |
| SCHEMBL28747907 | 0.71 | MAPT (0.50) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685123-B1 | SUBSTITUTED DIHYDROQUINAZOLINES II | BAYER HEALTHCARE AG (DE) | 2009-08-19 | — | — | EP | disclosed |
| EP-1685123-A2 | SUBSTITUTED DIHYDROQUINAZOLINES II | Bayer HealthCare AG (DE) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005047278-A2 | SUBSTITUTED DIHYDROQUINAZOLINES II | BAYER HEALTHCARE AG (DE) | 2005-05-26 | — | — | WO | disclosed |