Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 10/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27397322 | 0.83 | KDM4E (0.50) | MEN1LMNAKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL1129274 | 0.83 | ADORA2B (0.35) | GRM2MEN1LMNAHTTKMT2A | |
| SCHEMBL15798746 | 0.79 | KDM4E (0.36) | GRM2MEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL15799560 | 0.78 | KDM4E (0.35) | GRM2MEN1LMNAHTTKMT2A | |
| SCHEMBL10462174 | 0.76 | KDM4E (0.40) | MEN1KMT2ASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL22824347 | 0.76 | CNR2 (0.46) | GRM2LMNAKMT2ACNR1CNR2 | |
| SCHEMBL7750534 | 0.76 | ALDH1A1 (0.38) | GRM2KMT2ACNR1CNR2ALDH1A1 | |
| SCHEMBL26750149 | 0.75 | GRM2 (0.39) | GRM2MEN1LMNAHTTKMT2A | |
| SCHEMBL13448507 | 0.75 | GRM2 (0.43) | GRM2SMN1; SMN2ALDH1A1L3MBTL1HPGD | |
| SCHEMBL1201357 | 0.75 | ALDH1A1 (0.51) | MEN1LMNAKMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1158845-A | New N-alkyl-cyano pyridone synthesizing method | CHEMICAL COLLEGE DALIAN SCIENC (CN) | 1997-09-10 | — | — | CN | claimed |
| EP-2134701-A1 | 3-CYANO-4-(4-PHENYL-PIPERIDIN-1-YL)-PYRIDIN-2-ONE DERIVATIVES | Ortho-McNeil-Janssen Pharmaceuticals, Inc. (US) | 2009-12-23 | — | — | EP | disclosed |
| EP-2134690-A1 | 1,4-DISUBSTITUTED 3-CYANO-PYRIDONE DERIVATIVES AND THEIR USE AS POSITIVE MGLUR2 -RECEPTOR MODULATORS | Ortho-McNeil-Janssen Pharmaceuticals, Inc. (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008107480-A1 | 1,4-DISUBSTITUTED 3-CYANO-PYRIDONE DERIVATIVES AND THEIR USE AS POSITIVE MGLUR2 -RECEPTOR MODULATORS | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC (US) | 2008-09-12 | — | — | WO | disclosed |
| WO-2008107479-A1 | 3-CYANO-4-(4-PHENYL-PIPERIDIN-1-YL)-PYRIDIN-2-ONE DERIVATIVES | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC (US) | 2008-09-12 | — | — | WO | disclosed |
| CN-1158845-A | New N-alkyl-cyano pyridone synthesizing method | CHEMICAL COLLEGE DALIAN SCIENC (CN) | 1997-09-10 | — | — | CN | disclosed |