Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 4/20 | 0.40 |
| ▸ | CKS1B | P61024 | 1/20 | 0.36 |
| ▸ | SKP1 | P63208 | 1/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.34 |
| ▸ | TACR2 | P21452 | 1/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
| ▸ | CASR | P41180 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3813909 | 0.91 | CNR1 (0.40) | CNR1CKS1BSKP1SKP2TRPV1 | |
| SCHEMBL3821251 | 0.90 | ABL1 (0.42) | CNR1SCN10AAXLHPGDS | |
| SCHEMBL3820971 | 0.90 | CNR1 (0.51) | CNR1TACR2CNR2 | |
| SCHEMBL3812006 | 0.83 | CNR1 (0.49) | CNR1SCN10ACNR2MAPTHPGDS | |
| SCHEMBL3821995 | 0.80 | CNR1 (0.51) | CNR1CKS1BSKP1SKP2CNR2 | |
| SCHEMBL1377750 | 0.79 | CNR1 (0.64) | CNR1KDM4EHTTKMT2ATACR2 | |
| SCHEMBL2704555 | 0.79 | CNR1 (0.64) | CNR1KDM4EHTTKMT2ATACR2 | |
| SCHEMBL1377747 | 0.79 | CNR1 (0.64) | CNR1KDM4EHTTKMT2ATACR2 | |
| SCHEMBL3819129 | 0.79 | CNR1 (0.49) | CNR1CNR2HPGDS | |
| SCHEMBL3924944 | 0.78 | CNR1 (0.45) | CNR1CKS1BSKP1SKP2SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035394-B1 | 2-PYRAZINECARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2009-08-19 | — | — | EP | claimed |