Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 3/20 | 0.51 |
| ▸ | CNR2 | P34972 | 7/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.38 |
| ▸ | CKS1B | P61024 | 1/20 | 0.36 |
| ▸ | SKP1 | P63208 | 1/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.36 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3819129 | 0.90 | CNR1 (0.49) | CNR1CNR2LRRK2EP300KDM1A | |
| SCHEMBL3821028 | 0.85 | NAMPT (0.38) | CNR1CKS1BSKP1SKP2GABRA5 | |
| SCHEMBL4013599 | 0.85 | CNR1 (0.57) | CNR1CNR2 | |
| SCHEMBL3816557 | 0.85 | GABRA1 (0.38) | CNR1CNR2CKS1BSKP1SKP2 | |
| SCHEMBL3813909 | 0.82 | CNR1 (0.40) | CNR1CNR2CKS1BSKP1SKP2 | |
| SCHEMBL3812006 | 0.81 | CNR1 (0.49) | CNR1CNR2GABRA5 | |
| SCHEMBL3822011 | 0.80 | CNR1 (0.40) | CNR1CNR2CKS1BSKP1SKP2 | |
| SCHEMBL3820971 | 0.80 | CNR1 (0.51) | CNR1CNR2GABRA5 | |
| SCHEMBL3817679 | 0.79 | CNR1 (0.49) | CNR1CNR2 | |
| SCHEMBL3818600 | 0.79 | CNR1 (0.49) | CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035394-B1 | 2-PYRAZINECARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2009-08-19 | — | — | EP | claimed |