Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.57 |
| ▸ | GSK3B | P49841 | 6/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | STK10 | O94804 | 2/20 | 0.44 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | QPCT | Q16769 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3818590 | 0.84 | GSK3B (0.51) | GSK3BSTK10SLK | |
| SCHEMBL6858139 | 0.82 | STK10 (0.46) | PTGS2GSK3BGRM5STK10SLK | |
| SCHEMBL18049431 | 0.82 | STK10 (0.46) | PTGS2GSK3BSTK10SLK | |
| SCHEMBL114611 | 0.82 | PTGS2 (0.67) | PTGS2GSK3B | |
| SCHEMBL18049419 | 0.80 | PTGS2 (0.60) | PTGS2GSK3BGRM5 | |
| SCHEMBL1133537 | 0.80 | PTGS2 (0.57) | PTGS2GSK3B | |
| SCHEMBL9474080 | 0.80 | PTGS2 (0.64) | PTGS2GSK3B | |
| SCHEMBL12424864 | 0.79 | NOTUM (0.44) | GRM5STK10SLKLMNAHPGD | |
| SCHEMBL18049412 | 0.79 | PTGS2 (0.59) | PTGS2GSK3B | |
| SCHEMBL18049416 | 0.78 | CAMK2D (0.62) | PTGS2GSK3BHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091531-A2 | PHENYL SUBSTITUTED MALEIMIDES AS MEDICAMENTS FOR BLOCKING DEGENERATIVE TISSUE DAMAGES BY INHIBITING MPT | Congenia S.r.l. (IT) | 2009-08-26 | — | — | EP | claimed |
| WO-2008067863-A2 | PHENYL SUBSTITUTED MALEIMIDES AS MEDICAMENTS FOR BLOCKING DEGENERATIVE TISSUE DAMAGES BY INHIBITING MPT | CONGENIA S.R.L. (IT) | 2008-06-12 | — | — | WO | claimed |