Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | DRD4 | P21917 | 17/20 | 0.66 |
| ▸ | HTR1A | P08908 | 1/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.62 |
| ▸ | HTR2A | P28223 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | DRD2 | P14416 | 4/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7652040 | 0.85 | MAPT (0.57) | NPC1GAAALDH1A1LMNAMAPT | |
| SCHEMBL383213 | 0.85 | DRD4 (0.77) | NPC1GAADRD4HTR1AADRA2C | |
| SCHEMBL9543721 | 0.82 | DRD4 (0.59) | NPC1GAADRD4HTR1AADRA2C | |
| SCHEMBL4814328 | 0.80 | NPC1 (1.00) | NPC1GAADRD4HTR1AADRA2C | |
| SCHEMBL4809921 | 0.80 | DRD4 (1.00) | NPC1GAADRD4HTR1AADRA2C | |
| SCHEMBL8689422 | 0.79 | DRD4 (1.00) | NPC1GAADRD4HTR1AADRA2C | |
| SCHEMBL9302827 | 0.78 | MAPT (0.71) | NPC1GAAALDH1A1LMNAMAPT | |
| SCHEMBL8687797 | 0.78 | DRD4 (1.00) | NPC1GAADRD4HTR1AADRA2C | |
| SCHEMBL6787298 | 0.78 | DRD4 (1.00) | NPC1GAADRD4HTR1AADRA2C | |
| SCHEMBL3318522 | 0.78 | PRMT1 (0.68) | DRD4HTR2AALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1074543-B1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA PHARMA CO LTD (JP) | 2012-01-25 | — | — | EP | disclosed |
| US-6420558-B1 | COMPOUNDS WITH AMIDINE GROUPS ANTAGONISTIC ACTIVITY, CELL ADHESION INHIBITORY ACTIVITY, HUMAN PLATELET AGGREGATION INHIBITORY ACTIVITY, AND THERAPEUTIC AGENTS | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1074543-A1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2001-02-07 | — | — | EP | disclosed |