Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.54 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.54 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | METAP1 | P53582 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 2/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL382255 | 0.85 | NPC1 (0.66) | MAPTNPC1ALDH1A1LMNAMAPK1 | |
| SCHEMBL7651404 | 0.82 | HTR2B (0.65) | MAPTALDH1A1LMNARAB9AHTR2B | |
| SCHEMBL382235 | 0.81 | MAPT (0.51) | MAPTNPC1ALDH1A1LMNAMAPK1 | |
| SCHEMBL22015905 | 0.79 | HPGD (0.65) | MAPTNPC1ALDH1A1LMNAMAPK1 | |
| SCHEMBL20188098 | 0.79 | HPGD (0.65) | MAPTNPC1ALDH1A1LMNAMAPK1 | |
| SCHEMBL6598953 | 0.79 | BCHE (0.56) | MAPTALDH1A1LMNARAB9AHTR2B | |
| SCHEMBL15474490 | 0.77 | MAPT (0.64) | MAPTLMNATP53TRPC3 | |
| SCHEMBL1192845 | 0.76 | ALDH1A1 (0.55) | MAPTNPC1ALDH1A1LMNAMAPK1 | |
| SCHEMBL1193289 | 0.75 | EGLN1 (0.68) | MAPTNPC1ALDH1A1LMNAMAPK1 | |
| Hydrochloric Acid SCHEMBL1192843 | 0.75 | MAPT (0.54) | MAPTNPC1ALDH1A1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | disclosed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | disclosed |