Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 16/20 | 0.77 |
| ▸ | NPC1 | O15118 | 1/20 | 0.74 |
| ▸ | GAA | P10253 | 1/20 | 0.74 |
| ▸ | HTR1A | P08908 | 1/20 | 0.64 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.64 |
| ▸ | HTR2A | P28223 | 1/20 | 0.64 |
| ▸ | DRD2 | P14416 | 3/20 | 0.61 |
| ▸ | DRD3 | P35462 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4809921 | 0.88 | DRD4 (1.00) | DRD4NPC1GAAHTR1AADRA2C | |
| SCHEMBL4814328 | 0.85 | NPC1 (1.00) | DRD4NPC1GAAHTR1AADRA2C | |
| SCHEMBL382255 | 0.85 | NPC1 (0.66) | DRD4NPC1GAAHTR1AADRA2C | |
| SCHEMBL8687797 | 0.83 | DRD4 (1.00) | DRD4NPC1GAAHTR1AADRA2C | |
| SCHEMBL6787298 | 0.83 | DRD4 (1.00) | DRD4NPC1GAAHTR1AADRA2C | |
| SCHEMBL23964171 | 0.82 | DRD4 (0.82) | DRD4NPC1GAAHTR1AADRA2C | |
| SCHEMBL7651404 | 0.82 | HTR2B (0.65) | HPGDKDM4EALDH1A1 | |
| SCHEMBL5157052 | 0.81 | HTT (0.84) | DRD4NPC1GAAHTR1AADRA2C | |
| SCHEMBL31267420 | 0.81 | DRD4 (0.72) | DRD4NPC1GAAHTR1AADRA2C | |
| SCHEMBL16795300 | 0.80 | DRD4 (0.67) | DRD4NPC1GAADRD2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1074543-B1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA PHARMA CO LTD (JP) | 2012-01-25 | — | — | EP | disclosed |
| US-6420558-B1 | COMPOUNDS WITH AMIDINE GROUPS ANTAGONISTIC ACTIVITY, CELL ADHESION INHIBITORY ACTIVITY, HUMAN PLATELET AGGREGATION INHIBITORY ACTIVITY, AND THERAPEUTIC AGENTS | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1074543-A1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2001-02-07 | — | — | EP | disclosed |