Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3822843 | 1.00 | GABRA1 (0.47) | GABRA1GABRG2GABRB3ALDH1A1MAPT | |
| SCHEMBL6808290 | 0.91 | GABRA1 (0.51) | GABRA1GABRG2GABRB3ALDH1A1MAPT | |
| SCHEMBL6025838 | 0.91 | GABRA1 (0.51) | GABRA1GABRG2GABRB3ALDH1A1MAPT | |
| Valine SCHEMBL6025321 | 0.78 | GABRA1 (0.40) | GABRA1GABRG2GABRB3ALDH1A1MAPT | |
| SCHEMBL2080589 | 0.75 | GABRA1 (0.44) | GABRA1GABRG2GABRB3ALDH1A1MAPT | |
| SCHEMBL2080588 | 0.75 | GABRA1 (0.44) | GABRA1GABRG2GABRB3ALDH1A1MAPT | |
| SCHEMBL12784706 | 0.75 | GABRA1 (0.44) | GABRA1GABRG2GABRB3ALDH1A1MAPT | |
| SCHEMBL3466020 | 0.74 | GABRA1 (0.42) | GABRA1GABRG2GABRB3ALDH1A1MAPT | |
| SCHEMBL3466019 | 0.74 | GABRA1 (0.42) | GABRA1GABRG2GABRB3ALDH1A1MAPT | |
| SCHEMBL7822858 | 0.73 | GABRA1 (0.56) | GABRA1GABRG2GABRB3ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937672-B1 | N-[(4,5-DIPHENYLPYRIMIDIN-2-YL)METHYL]AMINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR THERAPEUTIC USE | SANOFI AVENTIS (FR) | 2009-09-02 | — | — | EP | disclosed |
| US-7541361-B2 | N-[4,5-diphenylpyrimidin-2-yl)methyl]amine derivatives, the preparation thereof and their therapeutic use | SANOFI-AVENTIS (FR) | 2009-06-02 | — | — | US | disclosed |
| US-20080176867-A1 | N-[(4,5-DIPHENYLPYRIMIDIN-2-YL)METHYL]AMINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR THERAPEUTIC USE | SANOFI-AVENTIS (FR) | 2008-07-24 | — | — | US | disclosed |
| EP-1937672-A1 | N-[(4,5-DIPHENYLPYRIMIDIN-2-YL)METHYL]AMINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR THERAPEUTIC USE | Sanofi-Aventis (FR) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007006928-A1 | N-[(4,5-DIPHENYLPYRIMIDIN-2-YL)METHYL]AMINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR THERAPEUTIC USE | SANOFI-AVENTIS (FR) | 2007-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176867-A1 | N-[(4,5-DIPHENYLPYRIMIDIN-2-YL)METHYL]AMINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR THERAPEUTIC USE | NQO1, PRMT5, QDPR | GABRA1 2206/4885GABRG2 2824/4885GABRB3 1855/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.