Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 2/20 | 0.43 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.42 |
| ▸ | MLNR | O43193 | 2/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.41 |
| ▸ | ADK | P55263 | 1/20 | 0.41 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | PTGIR | P43119 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3823781 | 0.89 | PDK1 (0.46) | PDK1BCL2A1PDK2PDK4HSP90AA1 | |
| SCHEMBL3827716 | 0.89 | PDK1 (0.46) | PDK1BCL2A1PDK2PDK4HSP90AA1 | |
| SCHEMBL3830084 | 0.86 | PDK1 (0.49) | PDK1BCL2A1PDK2PDK4HSP90AA1 | |
| SCHEMBL3829755 | 0.85 | PDK1 (0.48) | PDK1BCL2A1MLNRPDK2PDK4 | |
| SCHEMBL3823489 | 0.84 | KDM4E (0.47) | PDK1BCL2A1PDK2PDK4HSP90AA1 | |
| SCHEMBL3824063 | 0.83 | PDK1 (0.48) | PDK1PDK2PDK4PDK3SLC2A1 | |
| SCHEMBL3821700 | 0.82 | CNR2 (0.49) | PDK1BCL2A1MLNRPDK2PDK4 | |
| SCHEMBL3828507 | 0.81 | PDK1 (0.45) | PDK1BCL2A1MLNRPDK2PDK4 | |
| SCHEMBL8179569 | 0.81 | PDK1 (0.43) | PDK1PDK2PDK4HSP90AA1HSP90AB1 | |
| SCHEMBL8180174 | 0.81 | PDK1 (0.43) | PDK1PDK2PDK4HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097379-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2009-09-09 | — | — | EP | claimed |
| WO-2008073936-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |