Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.39 |
| ▸ | PTGIR | P43119 | 2/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8195085 | 0.92 | CXCR2 (0.47) | KDM4ECXCR2POLBPDK1MAPK14 | |
| SCHEMBL3824063 | 0.87 | PDK1 (0.48) | KDM4ETSHRPDK1MAPK14SLC2A1 | |
| SCHEMBL3827716 | 0.86 | PDK1 (0.46) | CXCR2PDK1MAPK14BCL2A1PTGIR | |
| SCHEMBL3823781 | 0.86 | PDK1 (0.46) | CXCR2PDK1MAPK14BCL2A1PTGIR | |
| SCHEMBL3822951 | 0.84 | PDK1 (0.43) | CXCR2PDK1MAPK14MEN1KMT2A | |
| SCHEMBL3058261 | 0.84 | POLB (0.46) | KDM4ETSHRCXCR2POLBMAPT | |
| SCHEMBL3830084 | 0.83 | PDK1 (0.49) | CXCR2PDK1MAPK14MAPTMEN1 | |
| SCHEMBL3829755 | 0.82 | PDK1 (0.48) | CXCR2PDK1MAPK14BCL2A1SLC2A1 | |
| SCHEMBL3063300 | 0.81 | POLB (0.44) | KDM4ETSHRCXCR2POLBMAPT | |
| SCHEMBL3063698 | 0.81 | POLB (0.42) | KDM4ETSHRCXCR2POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097379-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2009-09-09 | — | — | EP | claimed |
| WO-2008073936-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |