Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 2/20 | 0.42 |
| ▸ | MET | P08581 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.37 |
| ▸ | ATR | Q13535 | 5/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | LDHB | P07195 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3461318 | 0.95 | MAPK1 (0.43) | CHEK2METROCK2MAPK1NTRK1 | |
| SCHEMBL3460832 | 0.91 | CHEK2 (0.40) | CHEK2METROCK2ROCK1MAPK1 | |
| SCHEMBL3460820 | 0.90 | MET (0.42) | CHEK2METROCK2ROCK1MAPK1 | |
| SCHEMBL3460492 | 0.89 | NTRK1 (0.40) | CHEK2METROCK2ROCK1MAPK1 | |
| SCHEMBL3460962 | 0.89 | NTRK1 (0.40) | CHEK2METROCK2ROCK1MAPK1 | |
| SCHEMBL3461957 | 0.89 | WDR5 (0.42) | CHEK2METMAPK1NTRK1ATR | |
| SCHEMBL3461186 | 0.87 | NTRK1 (0.43) | CHEK2METMAPK1NTRK1ATR | |
| SCHEMBL3462119 | 0.87 | MET (0.38) | CHEK2METROCK2ROCK1MAPK1 | |
| SCHEMBL3461568 | 0.87 | NTRK1 (0.40) | CHEK2METMAPK1NTRK1ATR | |
| SCHEMBL3460543 | 0.85 | MAPK1 (0.43) | CHEK2METMAPK1ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501514-A4 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2009-08-26 | — | — | EP | claimed |
| EP-1501514-A2 | PROTEIN KINASE MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2005-02-02 | — | — | EP | claimed |
| WO-2003093297-A2 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2003-11-13 | — | — | WO | claimed |