Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 11/20 | 0.55 |
| ▸ | ITGA2B | P08514 | 11/20 | 0.55 |
| ▸ | ITGAV | P06756 | 9/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7473366 | 0.93 | ITGB3 (0.49) | ITGB3ITGA2BITGAVALDH1A1USP2 | |
| SCHEMBL382306 | 0.92 | ITGB3 (0.65) | ITGB3ITGA2BITGAV | |
| SCHEMBL7473372 | 0.89 | ITGB3 (0.46) | ITGB3ITGA2BITGAVALDH1A1USP2 | |
| SCHEMBL382475 | 0.88 | ITGB3 (0.43) | ITGB3ITGA2BITGAVALDH1A1KMT2A | |
| SCHEMBL382346 | 0.85 | ITGB3 (0.46) | ITGB3ITGA2BITGAVALDH1A1USP2 | |
| SCHEMBL383234 | 0.84 | ITGB3 (0.69) | ITGB3ITGA2BITGAV | |
| SCHEMBL7461788 | 0.84 | ITGB3 (0.56) | ITGB3ITGA2BITGAV | |
| SCHEMBL382036 | 0.84 | ITGB3 (0.74) | ITGB3ITGA2BITGAV | |
| SCHEMBL383013 | 0.83 | ITGB3 (0.75) | ITGB3ITGA2BITGAV | |
| SCHEMBL382776 | 0.83 | ITGB3 (0.75) | ITGB3ITGA2BITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420558-B1 | COMPOUNDS WITH AMIDINE GROUPS ANTAGONISTIC ACTIVITY, CELL ADHESION INHIBITORY ACTIVITY, HUMAN PLATELET AGGREGATION INHIBITORY ACTIVITY, AND THERAPEUTIC AGENTS | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-07-16 | — | — | US | claimed |
| EP-1074543-B1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA PHARMA CO LTD (JP) | 2012-01-25 | — | — | EP | disclosed |
| US-6420558-B1 | COMPOUNDS WITH AMIDINE GROUPS ANTAGONISTIC ACTIVITY, CELL ADHESION INHIBITORY ACTIVITY, HUMAN PLATELET AGGREGATION INHIBITORY ACTIVITY, AND THERAPEUTIC AGENTS | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1074543-A1 | AMINOPIPERIDINE DERIVATIVES AS INTEGRIN ALPHA V BETA 3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2001-02-07 | — | — | EP | disclosed |