Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | HRH1 | P35367 | 2/20 | 0.51 |
| ▸ | GCK | P35557 | 11/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2071266 | 0.81 | HTR2A (0.57) | HTR2AHRH1HTR1BMTORSLC6A4 | |
| SCHEMBL8533233 | 0.80 | GCK (0.47) | GCKRIPK1 | |
| SCHEMBL2074077 | 0.76 | HTR2A (0.51) | HTR2AHRH1HTR1BMTORSLC6A4 | |
| SCHEMBL2075092 | 0.76 | HTR2A (0.51) | HTR2AHRH1HTR1BMTORSLC6A4 | |
| SCHEMBL2074606 | 0.74 | HTR2A (0.49) | HTR2AHRH1HTR1BMTORSLC6A4 | |
| SCHEMBL2073654 | 0.74 | SLC6A4 (0.48) | HTR2AHRH1HTR1BMTORSLC6A4 | |
| SCHEMBL29383013 | 0.74 | HRH1 (0.65) | HTR2AHRH1HTR1BMTORSLC6A4 | |
| SCHEMBL2074684 | 0.73 | SLC6A4 (0.50) | HTR2AHRH1HTR1BMTORSLC6A4 | |
| SCHEMBL8135643 | 0.72 | RIPK1 (0.47) | GCKRIPK1 | |
| SCHEMBL2981817 | 0.72 | DAO (0.49) | GCKRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957488-B1 | 3-AMINO-2-ARYLPROPYL AZAINDOLES AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2009-09-09 | — | — | EP | claimed |