Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 12/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.41 |
| ▸ | TACR1 | P25103 | 3/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3814247 | 0.88 | SLC6A2 (0.51) | SLC6A2SLC6A4SLC6A3TACR1HTR2C | |
| SCHEMBL3823147 | 0.86 | TACR1 (0.44) | SLC6A2SLC6A4SLC6A3TACR1 | |
| SCHEMBL3818883 | 0.86 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3NOS2 | |
| SCHEMBL3821207 | 0.84 | SLC6A2 (0.38) | SLC6A2SLC6A4SLC6A3TACR1 | |
| SCHEMBL3820758 | 0.83 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3NOS2 | |
| SCHEMBL3818638 | 0.83 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3TACR1NOS2 | |
| SCHEMBL3821333 | 0.82 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3NOS2 | |
| SCHEMBL3820183 | 0.80 | CTSL (0.36) | SLC6A2SLC6A4SLC6A3KDM1AMAOB | |
| SCHEMBL3818198 | 0.79 | NOS2 (0.47) | SLC6A2SLC6A4SLC6A3TACR1NOS2 | |
| SCHEMBL4306762 | 0.72 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3TACR1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091938-A1 | PIPERIDINYLAMINO-PYRIDAZINES AND THEIR USE AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008068277-A1 | PIPERIDINYLAMINO-PYRIDAZINES AND THEIR USE AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-06-12 | — | — | WO | disclosed |