Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SELP | P16109 | 1/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | ATP4A | P20648 | 4/20 | 0.33 |
| ▸ | ATP4B | P51164 | 4/20 | 0.33 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3824183 | 0.85 | NOX1 (0.45) | KDM4EALDH1A1MAPTHPGDNPC1 | |
| SCHEMBL3830694 | 0.83 | MEN1 (0.37) | MAPTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL8718582 | 0.83 | KDM4E (0.40) | KDM4EALDH1A1MAPTHPGDNPC1 | |
| SCHEMBL3824756 | 0.79 | SELP (0.40) | KDM4EALDH1A1MAPTHPGDNPC1 | |
| SCHEMBL3824090 | 0.79 | SELP (0.41) | KDM4EALDH1A1MAPTHPGDNPC1 | |
| SCHEMBL6609826 | 0.78 | NOX1 (0.51) | KDM4EALDH1A1MAPTHPGDNPC1 | |
| SCHEMBL3828923 | 0.73 | NOX1 (0.40) | KDM4EALDH1A1MAPTHPGDNPC1 | |
| SCHEMBL8720952 | 0.68 | MAPT (0.43) | KDM4EALDH1A1MAPTHPGDNPC1 | |
| SCHEMBL3826536 | 0.67 | MEN1 (0.48) | ALDH1A1MAPTNPC1RAB9AMEN1 | |
| SCHEMBL16448288 | 0.66 | ABCB1 (0.68) | ALDH1A1MAPTMEN1KMT2ASELP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0999835-B1 | IMIDAZOLE DERIVATIVES AS MDR MODULATORS | TAIJI BIOMEDICAL INC (US) | 2009-09-09 | — | — | EP | disclosed |
| EP-2082740-A2 | Use of imidazole derivatives as MDR modulators | Taiji Biomedical, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| EP-0999835-A4 | IMIDAZOLE DERIVATIVES AS MDR MODULATORS | ONTOGEN CORP (US) | 2004-08-25 | — | — | EP | disclosed |
| EP-0999835-A1 | IMIDAZOLE DERIVATIVES AS MDR MODULATORS | Ontogen Corporation (US) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999002155-A1 | IMIDAZOLE DERIVATIVES AS MDR MODULATORS | ONTOGEN CORPORATION (US) | 1999-01-21 | — | — | WO | disclosed |