Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | STAT1 | P42224 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8723120 | 0.91 | MAPT (0.36) | MAPTRXFP1NPC1RAB9AKDM4E | |
| SCHEMBL8718582 | 0.86 | KDM4E (0.40) | MAPTNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL3824183 | 0.82 | NOX1 (0.45) | MAPTRXFP1NOX1NPC1RAB9A | |
| SCHEMBL6609826 | 0.75 | NOX1 (0.51) | MAPTRXFP1NOX1NPC1RAB9A | |
| SCHEMBL3830694 | 0.73 | MEN1 (0.37) | MAPTNOX1NPC1RAB9AMEN1 | |
| SCHEMBL3826536 | 0.72 | MEN1 (0.48) | MAPTNOX1NPC1RAB9AALDH1A1 | |
| SCHEMBL3828923 | 0.70 | NOX1 (0.40) | MAPTRXFP1NOX1NPC1RAB9A | |
| SCHEMBL5708149 | 0.70 | TOP2A (0.49) | MAPTNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL3825381 | 0.68 | KDM4E (0.36) | MAPTNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL1660542 | 0.67 | NPC1 (0.67) | MAPTNPC1RAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5840721-A | INCREASE SENSITIVITY OF MULTIDRUG RESISTANT TUMOR CELLS TO ANTICANCER AGENTS | ONTOGEN CORPORATION (US) | 1998-11-24 | — | — | US | disclosed |