Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 5/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | STAT1 | P42224 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8720952 | 0.86 | MAPT (0.43) | KDM4EALDH1A1MAPTHPGDNPC1 | |
| SCHEMBL8723120 | 0.84 | MAPT (0.36) | KDM4EALDH1A1MAPTHPGDHTT | |
| SCHEMBL3825381 | 0.83 | KDM4E (0.36) | KDM4EALDH1A1MAPTHPGDNPC1 | |
| SCHEMBL3824756 | 0.72 | SELP (0.40) | KDM4EALDH1A1MAPTHPGDHTT | |
| SCHEMBL3824090 | 0.71 | SELP (0.41) | KDM4EALDH1A1MAPTHPGDHTT | |
| SCHEMBL3824183 | 0.68 | NOX1 (0.45) | KDM4EALDH1A1MAPTHPGDHTT | |
| SCHEMBL5708149 | 0.68 | TOP2A (0.49) | KDM4EALDH1A1MAPTHPGDNPC1 | |
| SCHEMBL3830694 | 0.66 | MEN1 (0.37) | MAPTHTTNPSR1NPC1RAB9A | |
| SCHEMBL1660542 | 0.65 | NPC1 (0.67) | KDM4EALDH1A1MAPTHPGDNPC1 | |
| SCHEMBL16448288 | 0.62 | ABCB1 (0.68) | ALDH1A1MAPTHTTSMN1; SMN2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5840721-A | INCREASE SENSITIVITY OF MULTIDRUG RESISTANT TUMOR CELLS TO ANTICANCER AGENTS | ONTOGEN CORPORATION (US) | 1998-11-24 | — | — | US | disclosed |