Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.61 |
| ▸ | GAA | P10253 | 6/20 | 0.61 |
| ▸ | MGAM | O43451 | 3/20 | 0.61 |
| ▸ | SI | P14410 | 3/20 | 0.61 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.61 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3829149 | 0.81 | SMN1; SMN2 (0.51) | KDM4EGAAHDAC1HDAC2HTT | |
| SCHEMBL3334264 | 0.80 | CA1 (0.61) | KDM4EHDAC1HDAC6HTTMEN1 | |
| SCHEMBL8707903 | 0.77 | KDM4E (0.67) | KDM4EGAAMGAMSIMGAM2 | |
| SCHEMBL16870304 | 0.77 | KDM4E (0.51) | KDM4EGAAMGAMSIMGAM2 | |
| SCHEMBL22761303 | 0.77 | KDM4E (0.73) | KDM4EHDAC1HDAC2HTTMEN1 | |
| SCHEMBL20214047 | 0.77 | HDAC1 (0.51) | KDM4EGAAHDAC1HDAC2RAB9A | |
| SCHEMBL1143676 | 0.76 | KDM4E (1.00) | KDM4EGAAMGAMSIMGAM2 | |
| SCHEMBL31527837 | 0.75 | MEN1 (0.51) | KDM4EGAAMGAMSIMGAM2 | |
| SCHEMBL28571808 | 0.75 | RAB9A (0.59) | KDM4EGAAMGAMSIMGAM2 | |
| SCHEMBL15554152 | 0.74 | MGAM (0.62) | KDM4EGAAMGAMSIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089380-B1 | SUBSTITUTED DIHYDROPYRAZOLONES AND USE THEREOF AS HIF-PROLYL-4 -HYDROXYLASE INHIBITORS | BAYER IP GMBH (DE) | 2016-06-29 | — | — | EP | disclosed |
| CN-101541785-B | Substituted dihydropyrazolones and use thereof as HIF-prolyl-4 -hydroxylase inhibitors | BAYER IP GMBH | 2014-03-12 | — | — | CN | disclosed |
| US-8524699-B2 | Substituted dihydropyrazolones and use thereof as HIF-prolyl-4-hydroxylase inhibitors | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-09-03 | — | — | US | disclosed |
| US-20120264704-A1 | SUBSTITUTED DIHYDROPYRAZOLONES AND USE THEREOF AS HIF-PROLYL-4 -HYDROXYLASE INHIBITORS | BAYER SCHERING PHARMA AG (DE) | 2012-10-18 | — | — | US | disclosed |
| CN-101541785-A | Substituted dihydropyrazolones and use thereof as HIF-prolyl-4 -hydroxylase inhibitors | BAYER SCHERING PHARMA AG (DE) | 2009-09-23 | — | — | CN | disclosed |
| EP-2089380-A1 | SUBSTITUTED DIHYDROPYRAZOLONES AND USE THEREOF AS HIF-PROLYL-4 -HYDROXYLASE INHIBITORS | Bayer Schering Pharma AG (DE) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008049538-A1 | SUBSTITUTED DIHYDROPYRAZOLONES AND USE THEREOF AS HIF-PROLYL-4 -HYDROXYLASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120264704-A1 | SUBSTITUTED DIHYDROPYRAZOLONES AND USE THEREOF AS HIF-PROLYL-4 -HYDROXYLASE INHIBITORS | HIF1AN, EGLN3, EGLN2 | KDM4E 123/4885GAA 712/4885MGAM 3804/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.