Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.61 |
| ▸ | CA2 | P00918 | 1/20 | 0.61 |
| ▸ | CA4 | P22748 | 1/20 | 0.61 |
| ▸ | CA5A | P35218 | 1/20 | 0.61 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 8/20 | 0.53 |
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3829149 | 0.80 | SMN1; SMN2 (0.51) | CA1CA2CA4CA5ACA5B | |
| SCHEMBL3825832 | 0.80 | KDM4E (0.61) | CA1CA2CA4CA5ACA5B | |
| SCHEMBL9018567 | 0.79 | ALDH1A1 (0.61) | CA1CA2CA4CA5ACA5B | |
| SCHEMBL9209215 | 0.79 | KDM4E (0.69) | CA1CA2CA4CA5ACA5B | |
| SCHEMBL12015939 | 0.78 | NPC1 (0.73) | CA1CA2CA4CA5ACA5B | |
| SCHEMBL2213286 | 0.77 | ALDH1A1 (0.59) | CA1CA2CA4CA5ACA5B | |
| SCHEMBL2380291 | 0.76 | NPC1 (0.58) | CA1CA2CA4CA5ACA5B | |
| SCHEMBL22761303 | 0.76 | KDM4E (0.73) | CA1CA2CA4CA5ACA5B | |
| SCHEMBL20214047 | 0.76 | HDAC1 (0.51) | NPC1RAB9AKDM4EPTGS1PTGS2 | |
| SCHEMBL17948201 | 0.75 | ALDH1A1 (0.57) | CA1CA2CA4CA5ACA5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020247819-A2 | METHODS OF TREATMENT WITH AMINOLEVULINIC ACID SYNTHASE 2 (ALAS2) MODULATORS | AGIOS PHARMACEUTICALS, INC. (US) | 2020-12-10 | — | — | WO | disclosed |
| WO-2014126580-A1 | PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO | DOW AGROSCIENCES LLC (US) | 2014-08-21 | — | — | WO | disclosed |
| WO-2013106254-A1 | PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO | DOW AGROSCIENCES LLC (US) | 2013-07-18 | — | — | WO | disclosed |
| US-8257931-B2 | Regulation of protein synthesis | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-09-04 | — | — | US | disclosed |
| US-8257931-B2 | Regulation of protein synthesis | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-09-04 | — | — | US | disclosed |
| US-20100144805-A1 | Regulation of protein synthesis | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-06-10 | — | — | US | disclosed |
| US-20100144805-A1 | Regulation of protein synthesis | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-06-10 | — | — | US | disclosed |
| EP-1868604-A2 | REGULATION OF PROTEIN SYNTHESIS BY INHIBITION OF EIF4E-EIF4G INTERACTION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006078942-A2 | REGULATION OF PROTEIN SYNTHESIS BY INHIBITION OF EIF4E-EIF4G INTERACTION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2006-07-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144805-A1 | Regulation of protein synthesis | EIF4EBP1, RNMT, NCBP1 | CA1 4136/4885CA2 4197/4885CA4 4293/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.