SCHEMBL3825843

SCHEMBL3825843

COc1ccc(S(=O)(=O)N2CC2C(N)=O)cc1OC

nearest known ligand 0.53

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 2/20 0.53
HCRTR2 O43614 2/20 0.53
GPBAR1 Q8TDU6 1/20 0.52
TSHR P16473 3/20 0.49
KMT2A Q03164 3/20 0.49
MAPT P10636 1/20 0.49
POLB P06746 1/20 0.49
MAPK1 P28482 1/20 0.49
MEN1 O00255 2/20 0.47
LMNA P02545 1/20 0.46
ALDH1A1 P00352 1/20 0.46
EPHX2 P34913 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
TP53 P04637 1/20 0.46
USP2 O75604 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3825839 0.88 HCRTR1 (0.52) HCRTR1HCRTR2GPBAR1TSHRKMT2A
SCHEMBL13964804 0.80 HCRTR1 (0.51) HCRTR1HCRTR2GPBAR1KMT2AMAPT
SCHEMBL13964809 0.80 HCRTR1 (0.51) HCRTR1HCRTR2GPBAR1KMT2AMAPT
SCHEMBL1979123 0.80 ANPEP (0.53) HCRTR1HCRTR2GPBAR1KMT2APOLB
SCHEMBL4182164 0.80 GPBAR1 (0.61) HCRTR1HCRTR2GPBAR1TSHRKMT2A
SCHEMBL4184732 0.80 GPBAR1 (0.61) HCRTR1HCRTR2GPBAR1TSHRKMT2A
SCHEMBL4184730 0.80 GPBAR1 (0.61) HCRTR1HCRTR2GPBAR1TSHRKMT2A
SCHEMBL4187502 0.78 HSD11B1 (0.58) HCRTR1HCRTR2GPBAR1TSHRPOLB
SCHEMBL3831713 0.78 POLB (0.52) KMT2APOLBLMNAALDH1A1L3MBTL1
SCHEMBL13964823 0.78 ALDH1A1 (0.55) HCRTR1HCRTR2KMT2AMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2099747-A1 RADIOLABELLING VIA FLUORINATION OF AZIRIDINES Bayer Schering Pharma Aktiengesellschaft (DE) 2009-09-16 EP disclosed
WO-2008083729-A1 RADIOLABELLING VIA FLUORINATION OF AZIRIDINES BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2008-07-17 WO disclosed
EP-1944288-A1 Radiolabelling via fluorination of aziridines Bayer Schering Pharma Aktiengesellschaft (DE) 2008-07-16 EP disclosed