Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 3/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | CCR8 | P51685 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1129893 | 0.80 | SMN1; SMN2 (0.34) | PARP1GSK3BABL1RIN1CHEK1 | |
| SCHEMBL15274777 | 0.77 | KDM4E (0.48) | KDM4EALDH1A1POLBCDK2DYRK1A | |
| SCHEMBL9355962 | 0.75 | KDM4E (0.53) | KDM4EALDH1A1POLBCDK2DYRK1A | |
| SCHEMBL9944047 | 0.74 | GSK3B (0.40) | KDM4EALDH1A1POLBCDK2DYRK1A | |
| SCHEMBL1129988 | 0.72 | GRM5 (0.41) | CDK2PARP1GSK3BABL1RIN1 | |
| SCHEMBL83683 | 0.70 | KDM4E (0.52) | KDM4EALDH1A1POLBLMNAMAPT | |
| SCHEMBL10999876 | 0.70 | KDM4E (0.48) | KDM4EALDH1A1POLBCDK2DYRK1A | |
| SCHEMBL30101160 | 0.70 | PARP1 (0.57) | KDM4EALDH1A1POLBLMNAPARP1 | |
| SCHEMBL27115830 | 0.69 | KDM4E (0.54) | KDM4EALDH1A1POLBCDK2DYRK1A | |
| SCHEMBL27115086 | 0.69 | KDM4E (0.40) | KDM4EALDH1A1POLBCDK2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603910-B1 | SUBSTITUTED 2-(DIAZA-BICYCLO-ALKYL)-PYRIMIDONE DERIVATIVES | SANOFI AVENTIS (FR) | 2009-08-26 | — | — | EP | disclosed |