Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | PDE2A | O00408 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3825889 | 0.74 | KDM4E (0.41) | GSK3BKDM4EALDH1A1POLBLMNA | |
| SCHEMBL9355962 | 0.73 | KDM4E (0.53) | KDM4EALDH1A1POLBLMNAGAA | |
| SCHEMBL21990343 | 0.68 | — | — | |
| SCHEMBL15274777 | 0.68 | KDM4E (0.48) | KDM4EALDH1A1POLBLMNAHPGD | |
| SCHEMBL27115085 | 0.67 | MEN1 (0.66) | KDM4EALDH1A1POLBLMNAGAA | |
| SCHEMBL27115830 | 0.67 | KDM4E (0.54) | KDM4EALDH1A1POLBLMNAHPGD | |
| SCHEMBL27115086 | 0.67 | KDM4E (0.40) | KDM4EALDH1A1POLBLMNAGAA | |
| SCHEMBL5231389 | 0.65 | SORT1 (0.40) | GSK3BKDM4EGAAHPGDMAPT | |
| SCHEMBL10999876 | 0.65 | KDM4E (0.48) | KDM4EALDH1A1POLBLMNAHPGD | |
| SCHEMBL30831552 | 0.65 | KDM4E (0.40) | KDM4EALDH1A1POLBLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2464632-A1 | PYRIMIDONE DERIVATIVES USED AS TAU PROTEIN KINASE 1 INHIBITORS | Mitsubishi Tanabe Pharma Corporation (JP) | 2012-06-20 | — | — | EP | disclosed |