Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 13/20 | 0.52 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.52 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1952690 | 0.91 | MET (0.52) | METCDKL5ALOX5APFEN1PDE4B | |
| SCHEMBL1952687 | 0.91 | MET (0.52) | METCDKL5ALOX5APFEN1PDE4B | |
| SCHEMBL1953122 | 0.89 | MET (0.54) | METCDKL5ALOX5APFEN1PDE4B | |
| SCHEMBL17835336 | 0.85 | MET (0.52) | METCDKL5ALOX5APFEN1PDE4B | |
| SCHEMBL3827962 | 0.85 | MET (0.53) | METCDKL5 | |
| SCHEMBL837214 | 0.84 | MET (0.54) | METCDKL5ALOX5APFEN1PDE4B | |
| SCHEMBL837213 | 0.84 | MET (0.54) | METCDKL5ALOX5APFEN1PDE4B | |
| SCHEMBL1949704 | 0.82 | MET (0.78) | METCDKL5KCNH2 | |
| SCHEMBL1949702 | 0.82 | MET (0.78) | METCDKL5KCNH2 | |
| SCHEMBL837321 | 0.82 | MET (0.55) | METCDKL5PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099447-A1 | IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS | Incyte Corporation (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008064157-A1 | IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2008-05-29 | — | — | WO | disclosed |