Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 6/20 | 0.56 |
| ▸ | TMIGD3 | P0DMS9 | 4/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.55 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.55 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 4/20 | 0.54 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.54 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.54 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7008070 | 0.86 | CDK1 (0.57) | CDK1TMIGD3ADORA2AADORA1ADORA2B | |
| SCHEMBL6919436 | 0.76 | CDK1 (0.58) | CDK1TMIGD3ADORA2AADORA1ADORA2B | |
| SCHEMBL7008061 | 0.74 | CDK1 (0.59) | CDK1TMIGD3ADORA2AADORA1ADORA2B | |
| SCHEMBL28068467 | 0.73 | TMIGD3 (0.77) | CDK1TMIGD3ADORA2AADORA1ADORA2B | |
| SCHEMBL28823370 | 0.73 | CDK1 (0.57) | CDK1CDK2CCNB2CCNB1CCNB3 | |
| SCHEMBL8677222 | 0.73 | CDK1 (0.57) | CDK1TMIGD3ADORA2AADORA1ADORA2B | |
| SCHEMBL7099130 | 0.73 | CDK1 (0.69) | CDK1CDK2CCNB2CCNB1CCNB3 | |
| SCHEMBL2098867 | 0.73 | CDK1 (0.63) | CDK1TMIGD3ADORA2AADORA1ADORA2B | |
| SCHEMBL4382069 | 0.72 | CDK1 (1.00) | CDK1TMIGD3ADORA2AADORA1ADORA2B | |
| SCHEMBL7006036 | 0.71 | ADORA2A (0.66) | CDK1TMIGD3ADORA2AADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104603113-B | Novel 2, 3-dihydro-1H-imidazo {1,2-a } pyrimidin-5-one and 1,2,3, 4-tetrahydropyrimidino {1,2-a } pyrimidin-6-one derivatives comprising substituted morpholines, preparation thereof and pharmaceutical use thereof | 赛诺菲 | 2020-01-21 | — | — | CN | disclosed |
| EP-2094699-A2 | NEW IMIDAZOLONE DERIVATIVES, PREPARATION THEREOF AS DRUGS, PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF AS PROTEIN KINASE INHIBITORS, IN PARTICULAR CDC7 | Sanofi-Aventis (FR) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008046982-A2 | NEW IMIDAZOLONE DERIVATIVES, PREPARATION THEREOF AS DRUGS, PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF AS PROTEIN KINASE INHIBITORS, IN PARTICULAR CDC7 | SANOFI-AVENTIS (FR) | 2008-04-24 | — | — | WO | disclosed |
| EP-1261603-B1 | FLAVONE DERIVATIVES, PREPARATION METHOD AND USE AS MEDICINES | AVENTIS PHARMA SA (FR) | 2006-08-16 | — | — | EP | disclosed |
| EP-1633738-A2 | NOVEL INDOLE DERIVATIVES, METHOD OF PREPARING SAME IN THE FORM OF MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND, IN PARTICULAR, KDR INHIBITORS | Aventis Pharma S.A. (FR) | 2006-03-15 | — | — | EP | disclosed |
| EP-1532134-A1 | NOVEL THIOPHENE ACYL HYDRAZINO DERIVATIVES, METHOD FOR PREPARING SAME, USE THEREOF AS MEDICINES, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE | Aventis Pharma S.A. (FR) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004096792-A2 | NOVEL INDOLE DERIVATIVES, METHOD OF PREPARING SAME IN THE FORM OF MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND, IN PARTICULAR, KDR INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-11-11 | — | — | WO | disclosed |
| WO-2004007477-A1 | NOVEL THIOPHENE ACYL HYDRAZINO DERIVATIVES, METHOD FOR PREPARING SAME, USE THEREOF AS MEDICINES, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE | AVENTIS PHARMA S.A. (FR) | 2004-01-22 | — | — | WO | disclosed |
| EP-1261603-A1 | FLAVONE DERIVATIVES, PREPARATION METHOD AND USE AS MEDICINES | Aventis Pharma S.A. (FR) | 2002-12-04 | — | — | EP | disclosed |
| WO-2001064673-A1 | FLAVONE DERIVATIVES, PREPARATION METHOD AND USE AS MEDICINES | AVENTIS PHARMA S.A. (FR) | 2001-09-07 | — | — | WO | disclosed |