Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | FPR1 | P21462 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28364744 | 0.84 | ERCC1 (0.47) | SMN1; SMN2MEN1KMT2ANPSR1ALDH1A1 | |
| SCHEMBL30685188 | 0.82 | OGFRL1 (0.41) | SMN1; SMN2MEN1KMT2ANPSR1ALDH1A1 | |
| SCHEMBL27354994 | 0.82 | OGFRL1 (0.41) | SMN1; SMN2MEN1KMT2ANPSR1ALDH1A1 | |
| SCHEMBL22239400 | 0.81 | ALDH1A1 (0.40) | SMN1; SMN2TSHRMAPK1ALDH1A1CHRM2 | |
| SCHEMBL7803028 | 0.81 | CES1 (0.43) | EPHX2NPSR1ALDH1A1CYP1A2MAPT | |
| SCHEMBL2557909 | 0.78 | EPHX2 (0.56) | EPHX2SMN1; SMN2TSHRMEN1KMT2A | |
| SCHEMBL28486082 | 0.77 | KEAP1 (0.43) | MEN1KMT2AALDH1A1KDM4EPOLB | |
| SCHEMBL22291950 | 0.74 | KMT2A (0.49) | SMN1; SMN2TSHRMAPK1MEN1KMT2A | |
| SCHEMBL31668593 | 0.73 | GAA (0.40) | SMN1; SMN2FPR1MEN1KMT2ANPSR1 | |
| SCHEMBL12904736 | 0.73 | GAA (0.40) | SMN1; SMN2FPR1MEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210277018-A1 | NEW CRBN MODULATORS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-09-09 | — | — | US | disclosed |
| CN-104693039-B | A kind of amantadine analog derivative and its preparation method and application | 中山大学 | 2016-11-16 | — | — | CN | disclosed |
| US-9029695-B2 | Heteroaromatic semiconducting polymers | RAYNERGY TEK INC. (TW) | 2015-05-12 | — | — | US | disclosed |
| US-20140353628-A1 | Heteroaromatic Semiconducting polymers | RAYNERGY TEK INC. (TW) | 2014-12-04 | — | — | US | disclosed |
| EP-2094649-A2 | MATERIALS AND METHODS FOR CO-CRYSTAL CONTROLLED SOLID-STATE SYNTHESIS OF IMIDES AND IMINES | University of South Florida (US) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008073613-A2 | MATERIALS AND METHODS FOR CO-CRYSTAL CONTROLLED SOLID-STATE SYNTHESIS OF IMIDES AND IMINES | UNIVERSITY OF SOUTH FLORIDA (US) | 2008-06-19 | — | — | WO | disclosed |
| US-20080146772-A1 | MATERIALS AND METHODS FOR CO-CRYSTAL CONTROLLED SOLID-STATE SYNTHESIS OF IMIDES AND IMINES | UNIVERSITY OF SOUTH FLORIDA (US) | 2008-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210277018-A1 | NEW CRBN MODULATORS | CRBN, CRKL, CDR2 | EPHX2 4083/4885SMN1; SMN2 512/4885TSHR 3250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.