Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 8/20 | 0.41 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.39 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 2/20 | 0.34 |
| ▸ | MERTK | Q12866 | 2/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3825299 | 0.97 | PIM2 (0.44) | PIM1PIM3PIM2ATRACVR2A | |
| SCHEMBL14237447 | 0.97 | PIM2 (0.44) | PIM1PIM3PIM2ATRACVR2A | |
| SCHEMBL3836927 | 0.77 | ATR (0.46) | ATRACVR1AXLMERTK | |
| SCHEMBL3461535 | 0.77 | ATR (0.46) | ATRACVR1AXLMERTK | |
| SCHEMBL3460821 | 0.74 | ACVR2A (0.47) | PIM1PIM3PIM2ATRACVR2A | |
| SCHEMBL377034 | 0.74 | ALDH1A1 (0.34) | IRAK4 | |
| SCHEMBL1563282 | 0.73 | CHEK1 (0.32) | PIK3CD | |
| SCHEMBL17075698 | 0.72 | LDHA (0.37) | PIM1PIM3PIM2PIK3CD | |
| SCHEMBL376384 | 0.72 | HCRTR2 (0.36) | — | |
| SCHEMBL3462612 | 0.71 | ATR (0.55) | ATRPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501514-B1 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2012-12-19 | — | — | EP | disclosed |
| EP-1501514-A4 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2009-08-26 | — | — | EP | disclosed |
| EP-1501514-A2 | PROTEIN KINASE MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003093297-A2 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2003-11-13 | — | — | WO | disclosed |