Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TNKS | O95271 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6316045 | 0.81 | TSHR (0.58) | KDM4EKMT2AGRM1RAB9AHSD17B10 | |
| SCHEMBL18765295 | 0.79 | KDM4E (0.63) | KDM4EKMT2AGRM1RAB9AHSD17B10 | |
| SCHEMBL13627914 | 0.78 | P2RX7 (0.38) | KDM4EKMT2AGRM1SMN1; SMN2TNKS | |
| SCHEMBL29382234 | 0.76 | P2RX7 (0.41) | KDM4EKMT2AGRM1TNKSPARP1 | |
| SCHEMBL14507079 | 0.75 | KMT2A (0.58) | KDM4EKMT2AGRM1RAB9AHSD17B10 | |
| SCHEMBL10801846 | 0.73 | KDM4E (1.00) | KDM4EKMT2AGRM1RAB9AHSD17B10 | |
| SCHEMBL19095286 | 0.72 | P2RX7 (0.41) | KDM4EKMT2AGRM1 | |
| SCHEMBL5838645 | 0.72 | HSD17B10 (0.60) | KDM4ERAB9AHSD17B10NPC1TP53 | |
| SCHEMBL16656093 | 0.71 | KDM4E (0.40) | KDM4EKMT2ARAB9ASMN1; SMN2LMNA | |
| SCHEMBL27965649 | 0.71 | KDM4E (0.61) | KDM4EKMT2ARAB9AHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099447-A1 | IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS | Incyte Corporation (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008064157-A1 | IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2008-05-29 | — | — | WO | disclosed |