Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 15/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3828180 | 0.86 | ATM (0.43) | ATML3MBTL1EGLN1POLBHIF1A | |
| SCHEMBL2579371 | 0.85 | EGLN1 (0.41) | EGLN1HIF1A | |
| SCHEMBL2582355 | 0.84 | EGLN1 (0.52) | EGLN1HIF1A | |
| SCHEMBL2579364 | 0.75 | EGLN1 (0.41) | EGLN1HIF1A | |
| SCHEMBL12101566 | 0.75 | L3MBTL1 (0.41) | L3MBTL1EGLN1POLBHIF1A | |
| SCHEMBL2583556 | 0.75 | EGLN1 (0.45) | EGLN1HIF1A | |
| SCHEMBL2581713 | 0.74 | EGLN1 (0.52) | EGLN1HIF1A | |
| SCHEMBL2580152 | 0.74 | GABRA1 (0.41) | EGLN1HIF1A | |
| SCHEMBL2583492 | 0.73 | EGLN1 (0.55) | EGLN1HIF1A | |
| SCHEMBL2578789 | 0.73 | EGLN1 (0.57) | EGLN1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097416-A1 | AZAQUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF | Amgen, Inc (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008076425-A1 | AZAQUINOLONE BASED COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF | AMGEN INC. (US) | 2008-06-26 | — | — | WO | disclosed |