Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 9/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 3/20 | 0.44 |
| ▸ | MMP3 | P08254 | 2/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4842475 | 0.94 | BACE1 (0.47) | RORCTRPA1MMP8MMP3BACE1 | |
| SCHEMBL4844942 | 0.94 | RORC (0.43) | RORCTRPA1MMP8MMP3BACE1 | |
| SCHEMBL4842623 | 0.94 | BACE1 (0.47) | RORCTRPA1MMP8MMP3BACE1 | |
| SCHEMBL4834178 | 0.94 | BACE1 (0.47) | RORCTRPA1MMP8MMP3BACE1 | |
| SCHEMBL4834162 | 0.94 | BACE1 (0.46) | RORCTRPA1MMP8MMP3BACE1 | |
| Potassium SCHEMBL4841487 | 0.94 | BACE1 (0.46) | RORCTRPA1MMP8MMP3BACE1 | |
| SCHEMBL4842113 | 0.94 | RORC (0.44) | RORCTRPA1MMP8MMP3BACE1 | |
| SCHEMBL4841476 | 0.94 | BACE1 (0.46) | RORCTRPA1MMP8MMP3BACE1 | |
| SCHEMBL4841534 | 0.94 | LIPG (0.45) | RORCTRPA1MMP8MMP3KMT2A | |
| SCHEMBL4033777 | 0.93 | BACE1 (0.45) | RORCTRPA1MMP8MMP3BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885695-B8 | INDOLINE COMPOUNDS | FOURNIER LAB SA (FR) | 2009-08-12 | — | — | EP | disclosed |
| EP-1885695-B1 | INDOLINE COMPOUNDS | FOURNIER LAB SA (FR) | 2009-02-25 | — | — | EP | disclosed |
| EP-1885695-A2 | NOVEL INDOLINE COMPOUNDS | LABORATOIRES FOURNIER S.A. (FR) | 2008-02-13 | — | — | EP | disclosed |
| WO-2007000550-A2 | NOVEL INDOLINE COMPOUNDS | LABORATOIRES FOURNIER S.A. (FR) | 2007-01-04 | — | — | WO | disclosed |