Sugi Predict

Sugi Predict / Compounds / SCHEMBL3827697

SCHEMBL3827697

SCHEMBL3827697

O=C(O)Cc1c(F)cccc1Br

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ AKR1B1 P15121 2/20 0.47
▸ KDM4E B2RXH2 1/20 0.42
▸ CXCL8 P10145 2/20 0.41
▸ HTT P42858 1/20 0.40
▸ EED O75530 2/20 0.39
▸ PTGS1 P23219 2/20 0.39
▸ PTGS2 P35354 2/20 0.39
▸ CES2 O00748 1/20 0.39
▸ CES1 P23141 1/20 0.39
▸ KMT2A Q03164 2/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ ALDH1A1 P00352 1/20 0.37
▸ HPGD P15428 1/20 0.37
▸ NPC1 O15118 1/20 0.37
▸ POLB P06746 1/20 0.37
▸ MAPT P10636 1/20 0.37
▸ ALB P02768 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29664382 1.00 AKR1B1 (0.47) AKR1B1KDM4ECXCL8HTTEED
SCHEMBL503912 0.86 AKR1B1 (0.56) AKR1B1KDM4ECXCL8PTGS1PTGS2
SCHEMBL19475267 0.86 AKR1B1 (0.56) AKR1B1KDM4EHTTPTGS1KMT2A
Hydrochloric Acid SCHEMBL1372001 0.84 AKR1B1 (0.54) AKR1B1KDM4ECXCL8PTGS1PTGS2
SCHEMBL14218104 0.83 HTT (0.39) KDM4EHTTEEDCES2CES1
SCHEMBL23039525 0.79 SMN1; SMN2 (0.43) HTTKMT2AALDH1A1NPC1
SCHEMBL29672849 0.79 SMN1; SMN2 (0.43) HTTKMT2AALDH1A1NPC1
SCHEMBL23270679 0.79 SMN1; SMN2 (0.50) KDM4EHTTEEDKMT2AMEN1
SCHEMBL28784843 0.78 AKR1B1 (0.50) AKR1B1KDM4ECXCL8PTGS1PTGS2
SCHEMBL13287336 0.78 EED (0.41) KDM4EEEDKMT2AMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12540128-B2 Substituted pyridazinones as herbicides SYNGENTA CROP PROTECTION AG (CH) 2026-02-03 — — US disclosed
US-12540120-B2 Herbicidal compounds SYNGENTA CROP PROTECTION AG (CH) 2026-02-03 — — US disclosed
EP-4638442-A1 TRANSIENT RECEPTOR POTENTIAL VANILLOID 6 INHIBITORS Uniquest Pty Limited (AU) 2025-10-29 — — EP disclosed
US-20250171420-A1 MOLECULAR GLUE DEGRADERS AND METHODS OF USING THE SAME MONTE ROSA THERAPEUTICS AG (CH) 2025-05-29 — — US disclosed
EP-4540240-A1 MOLECULAR GLUE DEGRADERS AND METHODS OF USING THE SAME Monte Rosa Therapeutics AG (CH) 2025-04-23 — — EP disclosed
US-12162840-B2 Herbicidal compositions SYNGENTA CROP PROTECTION AG (CH) 2024-12-10 — — US disclosed
CN-114555563-B Substituted pyridazinones as herbicides 先正达农作物保护股份公司 2024-11-15 — — CN disclosed
EP-3999494-B1 SUBSTITUTED PYRIDAZINONES AS HERBICIDES SYNGENTA CROP PROTECTION AG (CH) 2024-09-11 — — EP disclosed
CN-114144409-B Substituted pyridazinones as herbicides 先正达农作物保护股份公司 2024-08-09 — — CN disclosed
WO-2024130342-A1 TRANSIENT RECEPTOR POTENTIAL VANILLOID 6 INHIBITORS UNIQUEST PTY LIMITED (AU) 2024-06-27 — — WO disclosed
WO-2021009334-A2 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2021-01-21 — — WO disclosed
WO-2021009335-A1 SUBSTITUTED PYRIDAZINONES AS HERBICIDES SYNGENTA CROP PROTECTION AG (CH) 2021-01-21 — — WO disclosed
WO-2021009335-A1 SUBSTITUTED PYRIDAZINONES AS HERBICIDES SYNGENTA CROP PROTECTION AG (CH) 2021-01-21 — — WO disclosed
WO-2021009334-A2 HERBICIDAL COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2021-01-21 — — WO disclosed
US-20210009530-A1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2021-01-14 — — US disclosed
EP-3737667-A1 HERBICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2020-11-18 — — EP disclosed
CN-111566094-A Herbicidal compounds 先正达参股股份有限公司 2020-08-21 — — CN disclosed
WO-2020114869-A1 HERBICIDAL COMPOSITIONS SYNGENTA PARTICIPATIONS AG (CH) 2020-06-11 — — WO disclosed
EP-2097385-A1 2-[1-PHENYL-5-HYDROXY OR METHOXY-4ALPHA-METHYL-HEXAHYDROCLOPENTA[F]INDAZOL-5-YL]ETHYL PHENYL DERIVATIVES AS GLUCOCORTICOID RECEPTOR LIGANDS Merck & Co., Inc. (US) 2009-09-09 — — EP disclosed
WO-2008051532-A1 2-[1-PHENYL-5-HYDROXY OR METHOXY-4ALPHA-METHYL-HEXAHYDROCLOPENTA[F]INDAZOL-5-YL]ETHYL PHENYL DERIVATIVES AS GLUCOCORTICOID RECEPTOR LIGANDS MERCK & CO., INC. (US) 2008-05-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12540128-B2 Substituted pyridazinones as herbicides CBR3, CBR1, CNPY2 AKR1B1 273/4885KDM4E 2187/4885CXCL8 4553/4885
US-12162840-B2 Herbicidal compositions DDT, HPD, PNPO AKR1B1 592/4885KDM4E 364/4885CXCL8 4695/4885
US-20210009530-A1 HERBICIDAL COMPOUNDS DDT, HPD, PGD AKR1B1 310/4885KDM4E 802/4885CXCL8 4755/4885
US-12540120-B2 Herbicidal compounds CBR3, CBR1, HACL2 AKR1B1 248/4885KDM4E 2018/4885CXCL8 4607/4885
US-20250171420-A1 MOLECULAR GLUE DEGRADERS AND METHODS OF USING THE SAME PSMA1, CSNK1G1, CSNK1A1 AKR1B1 1489/4885KDM4E 394/4885CXCL8 4594/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.