Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 8/20 | 0.35 |
| ▸ | CNR2 | P34972 | 8/20 | 0.35 |
| ▸ | RET | P07949 | 2/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.34 |
| ▸ | MLYCD | O95822 | 1/20 | 0.34 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3828156 | 1.00 | CNR1 (0.35) | CNR1CNR2RETTAS1R3TAS1R1 | |
| SCHEMBL3830189 | 0.91 | MAPT (0.37) | RETSYKSMN1; SMN2 | |
| SCHEMBL3830191 | 0.91 | MAPT (0.37) | RETSYKSMN1; SMN2 | |
| SCHEMBL4400971 | 0.88 | MLYCD (0.39) | CNR1CNR2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL3828162 | 0.88 | MLYCD (0.39) | CNR1CNR2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL3833160 | 0.86 | RET (0.38) | CNR1RETSYK | |
| SCHEMBL5820105 | 0.86 | KDM4E (0.36) | RET | |
| SCHEMBL5822553 | 0.86 | PTK2 (0.38) | RETTAS1R3TAS1R1TAS1R2SYK | |
| SCHEMBL4794491 | 0.85 | RET (0.36) | CNR1CNR2RETSYKSMN1; SMN2 | |
| SCHEMBL3833011 | 0.83 | MAPT (0.37) | RETSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2089018-A2 | METHODS OF TREATING COGNITIVE IMPAIRMENT AND DEMENTIA | Lexicon Pharmaceuticals, Inc. (US) | 2009-08-19 | — | — | EP | disclosed |
| WO-2008067121-A2 | METHODS OF TREATING COGNITIVE IMPAIRMENT AND DEMENTIA | LEXICON PHARMACEUTICALS, INC. (US) | 2008-06-05 | — | — | WO | disclosed |