Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 8/20 | 0.54 |
| ▸ | UCHL1 | P09936 | 7/20 | 0.49 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.42 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.39 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL382918 | 1.00 | DGAT1 (0.54) | DGAT1UCHL1USP30SOAT2TRIM24 | |
| SCHEMBL10258511 | 0.90 | UCHL1 (0.49) | DGAT1UCHL1USP30TRIM24 | |
| SCHEMBL10197562 | 0.90 | UCHL1 (0.49) | DGAT1UCHL1USP30TRIM24 | |
| SCHEMBL462604 | 0.83 | DGAT1 (0.58) | DGAT1SOAT2TRIM24 | |
| SCHEMBL10261211 | 0.83 | DGAT1 (0.58) | DGAT1SOAT2TRIM24 | |
| SCHEMBL462605 | 0.83 | DGAT1 (0.58) | DGAT1SOAT2TRIM24 | |
| SCHEMBL460678 | 0.83 | DGAT1 (0.56) | DGAT1UCHL1USP30SOAT2 | |
| SCHEMBL460676 | 0.83 | DGAT1 (0.56) | DGAT1UCHL1USP30SOAT2 | |
| SCHEMBL460677 | 0.83 | DGAT1 (0.56) | DGAT1UCHL1USP30SOAT2 | |
| SCHEMBL10197544 | 0.80 | DGAT1 (0.83) | DGAT1SOAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408744-A1 | BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | Schering Corporation (US) | 2012-01-25 | — | — | EP | disclosed |
| WO-2010107768-A1 | BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE | SCHERING CORPORATION (US) | 2010-09-23 | — | — | WO | disclosed |