Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | LIG1 | P18858 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30883941 | 0.71 | HSD17B3 (0.33) | FGFR1FGFR2FGFR4FGFR3JAK2 | |
| SCHEMBL29217668 | 0.71 | HSD17B3 (0.33) | FGFR1FGFR2FGFR4FGFR3JAK2 | |
| SCHEMBL27395617 | 0.66 | ALDH1A1 (0.39) | JAK2CA12CA9CA1CA2 | |
| SCHEMBL30634757 | 0.65 | JAK2 (0.36) | JAK2CA12CA9CA1CA2 | |
| SCHEMBL6641189 | 0.65 | MAPT (0.34) | JAK2CA12CA9HSD17B3TSHR | |
| Water SCHEMBL27538247 | 0.65 | ALDH1A1 (0.38) | JAK2CA12CA9CA1CA2 | |
| Water SCHEMBL27476632 | 0.65 | ALDH1A1 (0.38) | JAK2CA12CA9CA1CA2 | |
| SCHEMBL28031614 | 0.65 | ALDH1A1 (0.33) | LIG1MEN1ALDH1A1LMNAMAPT | |
| SCHEMBL1451866 | 0.64 | NOS2 (0.34) | JAK2CA12CA9HSD17B3SMN1; SMN2 | |
| SCHEMBL1451868 | 0.64 | NOS2 (0.34) | JAK2CA12CA9HSD17B3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097400-A2 | FUSED SUBSTITUTED AMINOPYRROLIDINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008082009-A2 | FUSED SUBSTITUTED AMINOPYRROLIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2008-07-10 | — | — | WO | disclosed |