Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 12/20 | 0.62 |
| ▸ | TLR4 | O00206 | 2/20 | 0.58 |
| ▸ | TLR2 | O60603 | 2/20 | 0.58 |
| ▸ | EGFR | P00533 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17070027 | 0.84 | FBP1 (0.64) | FBP1TLR4TLR2EGFRALDH1A1 | |
| SCHEMBL16632344 | 0.83 | PTGS2 (0.69) | FBP1TLR4TLR2EGFRALDH1A1 | |
| SCHEMBL16632342 | 0.83 | PTGS2 (0.69) | FBP1TLR4TLR2EGFRALDH1A1 | |
| SCHEMBL17070015 | 0.83 | FBP1 (0.62) | FBP1TLR4TLR2EGFRALDH1A1 | |
| SCHEMBL509742 | 0.81 | TLR4 (0.71) | FBP1TLR4TLR2EGFRALDH1A1 | |
| SCHEMBL509743 | 0.81 | TLR4 (0.71) | FBP1TLR4TLR2EGFRALDH1A1 | |
| SCHEMBL17070028 | 0.81 | FBP1 (0.60) | FBP1TLR4TLR2EGFRALDH1A1 | |
| SCHEMBL16562025 | 0.79 | FBP1 (0.57) | FBP1TLR4TLR2EGFRALDH1A1 | |
| SCHEMBL6910815 | 0.79 | FBP1 (0.78) | FBP1TLR4TLR2EGFRALDH1A1 | |
| SCHEMBL6910818 | 0.79 | FBP1 (0.78) | FBP1TLR4TLR2EGFRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2099794-A2 | THIAZOLYL COMPOUNDS USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008079873-A2 | THIAZOLYL COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-07-03 | — | — | WO | disclosed |