Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 7/20 | 0.49 |
| ▸ | LCK | P06239 | 4/20 | 0.49 |
| ▸ | ABL1 | P00519 | 2/20 | 0.45 |
| ▸ | BCR | P11274 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | CSF1R | P07333 | 3/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | BLK | P51451 | 1/20 | 0.43 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.43 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3825451 | 0.93 | BTK (0.51) | BTKLCKABL1BCRMAPT | |
| SCHEMBL3830993 | 0.90 | BTK (0.49) | BTKLCKMAPTKDM4ECSF1R | |
| SCHEMBL3830492 | 0.90 | BTK (0.46) | BTKLCKABL1BCRMAPT | |
| SCHEMBL3825126 | 0.90 | BTK (0.49) | BTKLCKMAPTKDM4ECSF1R | |
| SCHEMBL3825146 | 0.88 | BTK (0.44) | BTKLCKMAPTKDM4ECSF1R | |
| SCHEMBL3829780 | 0.87 | BTK (0.47) | BTKLCKABL1BCRMAPT | |
| SCHEMBL3824944 | 0.87 | BTK (0.46) | BTKLCKABL1BCRMAPT | |
| SCHEMBL3824777 | 0.87 | MAPT (0.48) | BTKLCKABL1MAPTKDM4E | |
| SCHEMBL3829466 | 0.87 | CSF1R (0.61) | LCKABL1CSF1RBRAFDAPK1 | |
| SCHEMBL3830881 | 0.87 | BTK (0.49) | BTKLCKMAPTKDM4ECSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651648-A4 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-09-02 | — | — | EP | disclosed |
| EP-1651648-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005011597-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2005-02-10 | — | — | WO | disclosed |